CAS 5104-49-4; 氟苯布洛芬; flurbiprofene

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货号

品牌

产品名称

规格

包装、参考价格

详情

F798106

MACKLIN

氟比洛芬

10mM in DMSO

131元/1ml;

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储存：-20°C

F838235

MACKLIN

氟比洛芬

98%

37元/1g; 102元/5g; 467元/25g; 1626元/100g; 7884元/500g;

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储存：室温
状态：白色粉末

F0371

TCI

Flurbiprofen

>98.0%(T)(HPLC)

890元/5G; 2750元/25G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₅H₁₃FO₂ = 244.27
外观与形状(20℃)	固体
Reaxys-RN	2054451
PubChem物质ID	87570142
SDBS (AIST Spectral DB)	19990
Merck Index (14)	4199
MDL编号	MFCD00079303

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 98.0 %
Melting point	113.0 to 116.0 ℃
Solubility in Methanol	almost transparency

物性(参考值)

熔点	113 ℃
水溶性	微溶
溶解性(可溶于)	甲醇

安全信息

图形或危害标志
信号词	危险
危险性说明	H301 : 吞咽会中毒。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

RTECS#

DU8341000

运输信息

UN编号	UN2811
类别	6.1
包装类别	III
监管条件代码(*)

916054

J&K

Flurbiprofen

99%, 非甾体抗炎化合物

212元/1G; 846元/5G; 2613元/25G;

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基本信息

分子式	C₁₅H₁₃FO₂
分子量	244.26
熔点	110-112
MDL编码	MFCD00079303
Beilstein	2054451
Merck	14,4199
EINECS 编号	225-827-6

安全信息

图形或危害标志
提示语	Danger
危险说明	H301
防范说明	P301+P310
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
RTECS	DU8341000

B22603

Alfa Aesar

2-Fluoro-alpha-methyl-4-biphenylacetic acid

99%

1382元/1g; 5157元/5g; 18959元/25g;

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应用
A cyclooxygenase inhibitor

基本信息

MDL
MFCD00079303

EINECS
225-827-6

分子式
C₁₅H₁₃FO₂

分子量
244.27

熔点
112-114°

灵敏度
Ambient temperatures.

形态
Powder

Merck
14,4199

GHS危害和防范说明

GHS符号

Hazard Statements
H301-H315-H319-H335
Toxic if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
III

危险类别
25-36/37/38
Toxic if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
DU8341000

TSCA
否

F8514

Sigma-Aldrich

Flurbiprofen

cyclooxygenase inhibitor

1237.7元/1 G; 4635.9元/5 G; 11182.7元/25 G;

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产品说明

应用

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

包装

1, 5, 25 g in poly bottle

生化/生理作用

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

基本信息

线性分子式	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
分子量	244.26
EC 号	225-827-6
MDL编号	MFCD00079303
PubChem化学物质编号	24894968

产品性质

质量水平	100
生物来源	synthetic
测定	≥98.5% (HPLC)
形式	powder
颜色	white to off-white
mp	110-112 ℃ (lit.)
溶解性	methanol: 50 mg/mL
作用机制	enzyme \| inhibits
抗生素抗菌谱	fungi
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559), PTGS1(5742), PTGS2(5743) rat ... Ptgs1(24693)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

F0285200

Flurbiprofen

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
分子量	244.26
MDL编号	MFCD00079303
PubChem化学物质编号	329799649
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
mp	110-112 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... PTGS1(5742), PTGS2(5743)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310 + P330
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0002271

Flurbiprofen for peak identification

CRS, European Pharmacopoeia (EP) Reference Standard

1341.2元/ ;

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产品说明

一般描述

生化/生理作用

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
分子量	244.26
MDL编号	MFCD00079303

产品性质

manufacturer/tradename	EDQM
mp	110-112 ℃ (lit.)
储存温度	2-8℃
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1285750

USP

Flurbiprofen

United States Pharmacopeia (USP) Reference Standard

3231.47元/200 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
分子量	244.26
MDL编号	MFCD00079303
PubChem化学物质编号	329749901
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	110-112 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... PTGS1(5742), PTGS2(5743)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1499

Supelco

Flurbiprofen

Pharmaceutical Secondary Standard; Certified Reference Material

1085.85元/500 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flurbiprofen is a non-selective, non-steroidal anti-inflammatory drug (NSAID) that is widely used against rheumatoid arthritis. It is also effective against vernal keratoconjunctivitis, post-operative ocular inflammation, herpetic stromal keratitis, excimer laser photorefractive keratectomy and ocular gingivitis.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Flurbiprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various analytical techniques.

生化/生理作用

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA3047 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
分子量	244.26
EC 号	225-827-6
MDL编号	MFCD00079303
PubChem化学物质编号	329823420
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	110-112 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur F0285200 traceable to USP 1285750
储存温度	2-30℃
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... PTGS1(5742), PTGS2(5743)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

463477

Fluorochem

Flurbiprofen

95%

418元/1g; 1232元/5g; 2398元/10g; 3630元/25g;

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基本信息

CAS Number	5104-49-4
MDL Number	MFCD00079303
Melting Point	113℃

安全信息

图形或危害标志
危险性说明	H301: Toxic if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.