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CAS: 51-35-4
分子式: C5H9NO3
分子量: 131.13
熔点: 274-275℃
中文名称: 
反-4-羟基-L-脯氨酸
L-4-羟基脯氨酸
反式-4-羟基-L-脯氨酸
4-羟基-2-羧基吡咯啶
4-羟基吡啶烷-2-羧酸
4-羟基-L-脯氨酸
L-羟基脯氨酸
英文名称: 
Trans-L-4-hydroxyproline
L-Proline, 4-hydroxy-, trans
L-4-Hydroxyproline
4-hydroxyproline
hydroxy-l-proline
hydroxyproline
l-hydroxyproline
trans-4-hydroxyproline
trans-hydroxyproline
trans-l-hydroxyproline
trans-4-hydroxy-l-proline
4-Hydroxy-L-proline
L-Proline,4-hydroxy-,trans
展开更多英文名
用途: 用作生化试剂。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
L811195MACKLINL-羟基脯氨酸99%26元/5g;   43元/25g;   77元/100g;   234元/500g;   998元/2.5kg;   展开
储存:室温
状态:白色到灰白色固体
折射率:-75.5 ° (C=4, H2O)
L823476MACKLINL-羟基脯氨酸分析对照品152元/20mg;   展开
储存:室温
状态:白色到淡奶油色结晶粉末
折射率:-75.5 ° (C=4, H2O)
H0296TCItrans-4-Hydroxy-L-proline>99.0%(T)(HPLC)185元/5G;   420元/25G;   950元/100G;   展开

基本信息

纯度/分析方法>99.0%(T)(HPLC)
分子式/分子量C5H9NO3 = 131.13
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN471933
PubChem物质ID87570719
Merck Index (14)4840
MDL编号MFCD00064320

技术规格

AppearanceWhite powder to crystaline
Purity(HPLC)min. 99.0 area%
Purity(Nonaqueous Titration)min. 99.0 %
Specific rotation [a]20/D-74.0 to -77.0 deg(C=4, H2O)
Solubility in Wateralmost transparency

物性(参考值)

比旋光度 [α]D-75.5° (C=4,H2O)
249313J&Ktrans-4-Hydroxy-L-proline99%72元/25G;   186元/100G;   743元/500G;   展开

基本信息

分子式C5H9NO3
分子量131.13
熔点273
比旋光度([α]20D)-75.6 (C=1, H2O)
MDL编码MFCD00064320
EINECS 编号200-091-9

安全信息

防范说明P262
WGK3
RTECSTW3586500
TSCA
A11851Alfa Aesartrans-4-Hydroxy-L-proline99+%279元/10g;   434元/25g;   1473元/100g;   展开

应用
trans-4-Hydroxy-L-proline is used as a reagent for the preparation of neuroexcitatory kainoids and antifungal echinocandins. It is also involved in the synthesis of chiral ligands for enantioselective ethylation of aldehydes.

备注
Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00064320

EINECS
200-091-9

分子式
C5H9NO3

分子量
131.13

熔点
270-273° dec.

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water.

Beilstein
471933

Merck
14,4840

安全信息

RTECS
TW3586500

TSCA

R11106Alfa Aesartrans-4-Hydroxy-L-proline Standard solution100ppm210元/1ml;   展开
PH018681(2S)-4-Hydroxy-2-pyrrolidinecarboxylic acidAldrichCPR1143.73元/1 G;   展开

产品说明

其他说明

Please note that sigma-aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. sigma-aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.
NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

基本信息

线性分子式C5H9O3N1
MDL编号MFCD00065580

产品性质

形式crystals
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3?,4-/m0/s1
InChI keyPMMYEEVYMWASQN-BKLSDQPFSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
H5534Sigma-Aldrichtrans-4-Hydroxy-L-prolineBioReagent, suitable for cell culture, ≥98.5%467.42元/10 MG;   3753.5元/25 G;   12535.2元/100 G;   64024.9元/1 KG;   展开

产品说明

包装

10 mg in glass bottle
25, 100 g in poly bottle
1 kg in poly bottle

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
PubChem化学物质编号24895700
NACRESNA.26

产品性质

质量水平200
产品线BioReagent
测定≥98.5%
形式crystalline
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
颜色 colorless
mp273 ℃ (dec.) (lit.)
溶解性H2O: 50 mg/mL
web metadata keyword.defaultchiral starting block, proline analogue, protein structure, prolyl hydroxylase, collagen, actinomycin
application(s)peptide synthesis
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
56250Sigma-Aldrichtrans-4-Hydroxy-L-prolineBioXtra, ≥99.0% (NT)637.42元/5 G;   866.47元/25 G;   2707.05元/100 G;   展开

产品说明

生化/生理作用

反式-4-羟基-L-脯氨酸被用作合成 (-)-secrinine 的起始原料;用于脯氨醇为基础的核苷酸类似物的合成,其中N-磷甲基基团连接脯氨醇环的氮原子,以及用于抗肿瘤抗生素 MPC1001 的 ABC 环系统的不对称合成中。
反式-4-羟基-L-脯氨酸用于有机合成 depsilairdin 类似物、多药耐药 P-糖蛋白的非竞争性拟肽抑制剂和 3-鸟嘌呤基-5-羟甲基-2-吡咯烷酮 (4) 或 3-腺嘌呤基-5-羟甲基-2-吡咯烷酮 (5) 核苷类似物。

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。
羟脯氨酸降解的酶和中间体

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
PubChem化学物质编号57651574
NACRESNA.26

产品性质

质量水平100
产品线BioXtra
测定≥99.0% (NT)
旋光性[α]20/D −76.0±1.5°, c = 5% in H2O
杂质≤0.3% foreign amino acids
灼烧残渣≤0.1% (as SO4)
缺失≤0.1% loss on drying, 110 ℃
颜色 colorless to white
mp273 ℃ (dec.) (lit.)
痕量阴离子chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg
痕量阳离子Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
application(s)peptide synthesis
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
个人防护装备Eyeshields, Gloves, type N95 (US)
H54409Sigma-Aldrichtrans-4-Hydroxy-L-proline≥99%345.27元/2.5 G;   558.88元/10 G;   707.22元/25 G;   1762.24元/100 G;   展开

产品说明

应用

合成神经兴奋 kainoid 和抗真菌棘白菌素的多功能试剂。也可用于合成手性配体,该配体可用于醛的不对称乙基化。

包装

2.5, 10, 25, 100 g in poly bottle

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
PubChem化学物质编号24895692
NACRESNA.22

产品性质

质量水平200
测定≥99%
形式crystalline powder
旋光性[α]25/D −75.6°, c = 1 in H2O
reaction suitabilityreaction type: solution phase peptide synthesis
颜色 white to off-white
mp273 ℃ (dec.) (lit.)
application(s)peptide synthesis
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
个人防护装备Eyeshields, Gloves, type N95 (US)
V900395Sigma-Aldrichtrans-4-Hydroxy-L-prolineVetec, reagent grade, 99%400.89元/100 G;   展开

产品说明

包装

25, 100 g in poly bottle

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
PubChem化学物质编号329829804

产品性质

等级reagent grade
产品线Vetec
测定99%
形式crystalline powder
reaction suitabilityreaction type: solution phase peptide synthesis
颜色 white
mp273 ℃ (dec.) (lit.)
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
PHR1939SupelcoHydroxyprolinePharmaceutical Secondary Standard; Certified Reference Material2391.32元/500 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

附注

To see an example of a Certificate of Analysis for this material enter LRAC2898 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
mp273 ℃ (dec.) (lit.)
application(s)pharmaceutical
格式neat
储存温度2-30℃
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
41875Supelcotrans-4-Hydroxy-L-prolineanalytical standard966.61元/100 MG;   展开

产品说明

应用

有关合适仪器技术的更多信息,请参考产品′s分析证书。如需进一步支持,请联系技术服务。

包装

无底玻璃瓶。内容物在插入式融锥内。

其他说明

动物结构蛋白(如胶原和弹性蛋白)的天然成分。

基本信息

经验(实验)分子式C5H9NO3
分子量131.13
Beilstein81441
EC 号200-091-9
MDL编号MFCD00064320
PubChem化学物质编号329756161
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥99% (TLC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
颜色 white
mp273 ℃ (dec.) (lit.)
格式neat
储存温度2-8℃
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
435556Amethysttrans-4-Hydroxy-L-proline99%, 用于合成68元/25G;   167元/100G;   569元/500G;   展开

基本信息

分子式C5H9NO3
分子量131.13
熔点273
比旋光度([α]20D)-75.6 (C=1, H2O)
MDL编码MFCD00064320
EINECS 编号200-091-9

安全信息

防范说明P262
WGK3
RTECSTW3586500
TSCA
M03214FluorochemH-Hyp-OH97%242元/25g;   638元/100g;   1144元/250g;   1672元/500g;   展开

基本信息

CAS Number51-35-4
MDL NumberMFCD00064320

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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