基本信息

技术规格

物性(参考值)

安全信息

图形或危害标志
信号词	危险
危险性说明	H301 : 吞咽会中毒。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

运输信息

基本信息

产品描述

Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。

靶点（IC50 & Targe）

Thymidylate synthase,

体外研究

Adrucil是一种尿嘧啶类似物，在C-5位置上有一个氟原子。利用和尿嘧啶一致的转运途径快速进入细胞。Adrucil在细胞内转化成几个活性代谢物：氟脱氧尿苷单磷酸盐(FdUMP)，氟脱氧尿苷三磷酸盐(FdUTP) 以及氟尿苷三磷酸盐 (FUTP)。Adrucil的代谢物FdUMP结合到TS核苷酸结合位点，与CH2THF形成稳定的三聚体，进而阻断了正常的底物dUMP的结合，抑制了dTMP的合成。Adrucil代谢物能够插入DNA，导致DNA双链断裂和细胞死亡。Adrucil的促凋亡作用可能和激活肿瘤抑制因子P53有关。P53功能缺失降低细胞对Adrucil的敏感性。[1]Adrucil抑制存活诱导各种细胞的凋亡。Adrucil 抑制鼻咽癌细胞系CNE2 和 HONE的生存能力[2]，Adrucil抑制Capan-1细胞的生存能力[3]，Adrucil抑制HT-29细胞的生存能力[4]，IC50 分别是 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM。

体内研究

Adrucil在治疗包括结肠癌，乳腺癌等各种癌症中有广泛应用。 [1]100毫克/千克 Adrucil显著抑制患有结肠癌小鼠的结肠Colon 38的生长，肿瘤复制时间(TD)，生长延缓因子(GDF)，和T/C分别是26.5 days，4.4, 和14%。[5]

细胞实验

Cell lines: 人类结肠癌细胞系 HT-29

Concentrations: ～25 μM

Incubation Time: 7天

Method: 在96孔板中Adrucil处理细胞7天后测量生长抑制(4000 HT-29 细胞/孔，在含10%透析的牛胎儿血清RPMI 1640 培养基中)；细胞附着过夜后加入增加浓度的Adrucil。在培养结束时，细胞用磷酸盐缓冲盐水(pH 7.4)清洗3次，用10%三氯乙酸在4 ℃下固定 60分钟。用去离子水洗5次，加入0.4% 磺酰罗丹明溶液在室温染色15分钟。未被磺酰罗丹明着色的通过1%冰乙酸漂洗去除。然后，着色的细胞蛋白质干燥，溶解于10 mM Tris-HCl。探测器在540nm波长处测定光密度值。

(Only for Reference)

动物实验

Animal Models: 38小鼠结肠癌结肠38

Formulation: PBS

Dosages: 100毫克/千克

Administration: 每周一次腹腔注射

(Only for Reference)

参考文献

[1] Longley DB, et al. Nat Rev Cancer, 2003, 3(5), 330-338.

[2] Qin L, et al. Biochem Biophys Res Commun, 2008, 371(3), 531-535.

[3] Shi X, et al. Oncology, 2002, 62(4), 354-362.

[4] Schwartz EL. J Biol Chem, 1995, 270(32), 19073-19077.

[5] Van Laar JA, et al. Cancer Chemother Pharmacol, 1996, 39(1

安全信息

图形或危害标志
提示语	Danger
危险说明	H301
防范说明	P301+P310
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
TSCA	是

应用
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

备注
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

基本信息

MDL
MFCD00006018

EINECS
200-085-6

分子式
C₄H₃FN₂O₂

分子量
130.08

熔点
ca 282° dec.

灵敏度
Light Sensitive. Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Beilstein
127172

Merck
14,4181

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H341-H360-H373
Harmful if swallowed.Suspected of causing genetic defects.May damage fertility or the unborn child.May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements
P260-P201-P280-P301+P312a-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray.Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
III

危险类别
61-22-48/22-68
May cause harm to the unborn child.Harmful if swallowed.Harmful: danger of serious damage to health by prolonged exposure if swallowed.Possible risk of irreversible effects.

安全等级
53-45
Avoid exposure - obtain special instructions before use.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
YR0350000

TSCA
是

基本信息

Ref#
22844

MDL
6018

分子式
C4 H3 F N2 O2

分子量
130.08

形态
White cryst powder

安全信息

危险等级
6.1

包装组
III

产品说明

一般描述

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.
Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

包装

1 g in Glass bottle

生化/生理作用

Primary Target
Aminoisobutyrate-pyruvate aminotransferase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 40 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

应用

5-氟尿嘧啶被用于诱导细胞凋亡。它被用作化学增敏剂。

包装

1, 5, 10 g in glass bottle

生化/生理作用

一种有效的抗肿瘤药物，通过抑制胸苷酯合成酶来影响嘧啶的合成，从而耗尽细胞内的dTTP池。其代谢产物为核糖核酸和脱氧核糖核酸，可与RNA和DNA结合。用5-FU处理细胞可导致细胞在S-期积累，并已被证明其可诱导p53依赖的凋亡。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

一般描述

5-氟尿嘧啶是一种抗肿瘤剂，广泛应用于各种恶性肿瘤的治疗。

应用

5-氟尿嘧啶可用作分析标准品，用于通过毛细管电泳测定医院污水和通过色谱技术测定生物样品和环境样品中的分析物。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

应用

5-氟尿嘧啶 (5-FU) 可作为前体制备5-FU衍生物，如1-酰氧烷基-5-氟尿嘧啶、3-酰氧烷基-5-氟尿嘧啶、1,3-双(酰氧烷基)-5-氟尿嘧啶和1-己基氨甲酰-5-氟尿嘧啶 (HCFU)，作为有效的抗肿瘤剂。它还可用于合成对癌细胞的细胞毒性超过氟尿嘧啶的5-5FU/偶氮二醇烯鎓。

包装

1, 5 g in glass bottle

生化/生理作用

5-氟尿嘧啶(5-FU)是一种有效的抗肿瘤药，可通过抑制胸苷酸合成酶而影响嘧啶合成，从而耗尽细胞内dTTP储库。它的代谢物核糖核苷酸和脱氧核糖核苷酸可以整合到RNA和DNA中。用5-FU处理细胞会导致S期细胞积累，并且已被证明可诱导p53依赖性细胞凋亡。

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P202 - P264 - P270 - P280 - P301 + P310 - P405
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Fluorouracil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by different analytical techniques.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3468 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 40 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H351
预防措施声明	P201 - P202 - P264 - P270 - P280 - P301 + P310
危险分类	Acute Tox. 3 Oral - Carc. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

基本信息

安全信息

图形或危害标志
提示语	Danger
危险说明	H301
防范说明	P301+P310
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
TSCA	是

基本信息

安全信息

图形或危害标志
危险性说明	H301: Toxic if swallowed. H312: Harmful in contact with skin. H319: Causes serious eye irritation. H335: May cause respiratory irritation. H340: May cause genetic defects oral. H360: May damage fertility or the unborn child oral.
防范说明	P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P233: Keep container tightly closed. P260: Do not breathe P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear P281: Use personal protective equipment as required. P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313: IF exposed or concerned: Get medical advice/ attention. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P322: Specific measures (see . on this label). P330: Rinse mouth. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P363: Wash contaminated clothing before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.