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CAS: 501-30-4
分子式: C6H6O4
分子量: 142.11
熔点: 151-156℃
中文名称: 
曲菌酸
5-羟基-2-羟甲基-4-哌弄
曲酸
5-羟基-2-羟甲基-4H-吡喃-4-酮
麴酸
英文名称: 
kojic
kojicacid
4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-
5-hydroxy-2-(hydroxymethyl)-4H-Pyran-4-one
5-Hydroxy-2-(hydroxymethyl)-4-pyrone
5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on
用途: 用作定量分析三价铁的试剂。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
K812221MACKLIN曲酸99%44元/25g;   88元/100g;   185元/500g;   915元/2.5kg;   展开
储存:室温
状态:白色到黄色或棕色粉末
K796819MACKLIN曲酸10mM in DMSO185元/1ml;   展开
储存:-20°C
状态:液体
K0010TCIKojic Acid>98.0%(T)515元/25G;   1075元/100G;   4480元/500G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C6H6O4 = 142.11
外观与形状(20℃)固体
Reaxys-RN120895
PubChem物质ID87571949
SDBS (AIST Spectral DB)10302
Merck Index (14)5317
MDL编号MFCD00006580

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(Neutralization titration)min. 98.0 %
Melting point154.0 to 158.0 ℃
Solubility in Methanolalmost transparency

物性(参考值)

熔点154 ℃
最大吸收波长269(CHCl3) nm
水溶性可溶
溶解性(可溶于)丙酮,甲醇,乙醇
溶解性(微溶于)乙醚
溶解性(不溶于)

相关法规

RTECS#UQ0875000
323880J&KKojic Acid99%80元/5G;   322元/25G;   998元/100G;   4122元/500G;   展开

基本信息

分子式C6H6O4
分子量142.11
熔点152-155
MDL编码MFCD00006580
Beilstein120895
Merck14,5317
EINECS 编号207-922-4

安全信息

防范说明P260
P262
WGK3
RTECSUQ0875000
TSCA
A10760Alfa AesarKojic Acid99%647元/5g;   2742元/25g;   8756元/100g;   展开

应用
Kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors and in cosmetics to lighten skin. It is used to treat skin diseases like melasma as it has antibacterial and antifungal properties. It is used as a chelation agent that inhibits melanin production and also as a tyrosine kinase inhibitor.

备注
Should be stored at room temperature. Stable under recommended storage conditions. Incompatible with oxidizing agents and bases.

基本信息

MDL
MFCD00006580

EINECS
207-922-4

分子式
C6H6O4

分子量
142.11

熔点
152-155°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water, acetone (freely soluble), ethanol (freely soluble), methanol, DMSO, ethyl acetate (slightly soluble), chloroform (slightly soluble), pydidine (slightly soluble) and ether (slightly soluble). Insoluble in benzene.

Beilstein
120895

Merck
14,5317

GHS危害和防范说明

GHS符号

Hazard Statements
H351
Suspected of causing cancer.

Precautionary Statements
P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
40
Limited evidence of a carcinogenic effect.

安全等级
36/37-60
Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
UQ0875000

TSCA

C20522Alfa AesarKojic Acid99%1857元/5g;   8103元/25g;   24086元/100g;   110222元/500g;   展开

基本信息

Ref#
20522

MDL
6580

分子式
C6 H6 O4

分子量
142.11

K3125Sigma-AldrichKojic Acid1600.92元/5 G;   2895.22元/10 G;   5756.5元/25 G;   展开

产品说明

应用

曲酸已被用于:

  • 作为豚鼠色素性远视 (PH) 中酪氨酸酶的抑制剂
  • 作为引用抑制剂标准用于筛选酪氨酸酶抑制
  • 作为 B16F10 黑色素瘤细胞中酪氨酸酶抑制的阳性对照

包装

5, 10, 25 g in poly bottle

生化/生理作用

曲酸来源于曲霉菌属、醋酸杆菌属和青霉属等真菌。它通过抑制酪氨酸酶而使黑色素合成停止。用于皮肤美白化妆品的制备。然而,曲酸在化妆品中的使用很少,因为其在长期储存期间的不稳定性和细胞毒性导致皮肤刺激。它是一种抗氧化剂,对锰和锌的螯合起辐射保护作用。
酪氨酸酶抑制剂。

基本信息

经验(实验)分子式C6H6O4
分子量142.11
Beilstein120895
EC 号207-922-4
MDL编号MFCD00006580
PubChem化学物质编号24896226
NACRESNA.77

产品性质

质量水平200
测定≥98.5% (HPLC)
形式powder
mp152-155 ℃ (lit.)
SMILES stringOCC1=CC(=O)C(O)=CO1
InChI1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChI keyBEJNERDRQOWKJM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
8.18461Sigma-Aldrich5-Hydroxy-2-hydroxymethyl-4H-pyran-4-onefor synthesis343.34元/10 G;   展开

产品说明

分析说明

Assay (HPLC, area%): ≥ 98.0 % (a/a)
Melting range (lower value): ≥ 150 °C
Melting range (upper value): ≤ 154 °C
Identity (IR): passes test

基本信息

经验(实验)分子式C6H6O4
分子量142.11
MDL编号MFCD00006580
EC索引号207-922-4

产品性质

质量水平200
测定≥98.0% (HPLC)
mp150-154 ℃
储存温度2-30℃
InChI1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChI keyBEJNERDRQOWKJM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
95197SupelcoKojic Acidanalytical standard1544.2元/100 MG;   展开

产品说明

一般描述

曲酸是一种酪氨酸酶抑制剂,由多种真菌(包括米曲霉)产生。由于它能够与黑色素形成过程中的含铜酪氨酸酶螯合,因此具有亮肤特性。曲酸也常用作普通化妆品、漂白化妆品等中的增白剂。它是一种治疗剂,有助于防止色素沉着。

应用

有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务部门。
曲酸可用作分析参考标准品,用于通过高效液相色谱紫外检测(HPLC-UV)测定皮肤增白化妆品和漂泊化妆品中的分析物。

生化/生理作用

酪氨酸酶抑制剂。

基本信息

经验(实验)分子式C6H6O4
分子量142.11
Beilstein120895
EC 号207-922-4
MDL编号MFCD00006580
PubChem化学物质编号329770427
NACRESNA.24

产品性质

等级analytical standard
质量水平100
测定≥99.0% (HPLC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp152-155 ℃ (lit.)
application(s)cleaning products
cosmetics
food and beverages
personal care
格式neat
SMILES stringOCC1=CC(=O)C(O)=CO1
InChI1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChI keyBEJNERDRQOWKJM-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
046837FluorochemKojic Acid99%308元/5g;   418元/25g;   616元/100g;   1232元/500g;   展开

基本信息

CAS Number501-30-4
MDL NumberMFCD00006580
Melting Point151-158℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H350: May cause cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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