CAS 500899-98-9; xie62-1004

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CAS:

500899-98-9

分子式:

C₂₃H₂₅NO₃

分子量:

363.4495

英文名称:

xie62-1004

2-[[[3,4-bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride

2-(3,4-bis(benzyloxy)benzylamino)ethanol hydrochloride

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货号

品牌

产品名称

规格

包装、参考价格

详情

B943764

MACKLIN

2-((3,4-双(苄氧基)苄基)氨基)乙醇

98%

358元/250mg; 517元/1g; 2246元/5g;

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储存：室温

SML2638

Sigma-Aldrich

XIE62-1004

≥98% (HPLC)

1467.7元/5 MG; 4730.28元/25 MG;

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产品说明

生化/生理作用

XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103).

基本信息

经验(实验)分子式	C₂₃H₂₅NO₃ · HCl
分子量	399.91

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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