| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| F809658 | MACKLIN | 5-氟-2'-脱氧尿苷 | 99% | 30元/100mg; 63元/500mg; 121元/1g; 459元/5g; 2005元/25g; | 展开 |
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| F795641 | MACKLIN | 5-氟-2'-脱氧尿苷 | 10mM in DMSO | 776元/1ml; | 展开 |
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| D2235 | TCI | 2'-Deoxy-5-fluorouridine | >98.0%(T)(HPLC) | 340元/100MG; 1200元/500MG; 1950元/1G; | 展开 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C9H11FN2O5 = 246.19 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 90221 | | PubChem物质ID | 87568673 | | SDBS (AIST Spectral DB) | 19323 | | Merck Index (14) | 4112 | | MDL编号 | MFCD00006530 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Melting point | 148.0 to 152.0 ℃ |
物性(参考值) | 熔点 | 150 ℃ | | 比旋光度 [α]D | 38° (C=1,H2O) | | 水溶性 | 可溶 | | 溶解性(可溶于) | 丙酮,醇 | | 溶解性(不溶于) | 苯,氯仿,乙醚 |
安全信息 | 图形或危害标志 |  | | 信号词 | 危险 | | 危险性说明 | H301 : 吞咽会中毒。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
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相关法规 运输信息 | UN编号 | UN2811 | | 类别 | 6.1 | | 包装类别 | III | | 监管条件代码(*) | |
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| 241600 | J&K | 2'-Deoxy-5-fluorouridine | 98%, 为抗代谢剂,可抑制PEPT1,GI50为5.1 μM | 108元/100MG; 274元/500MG; | 展开 |
基本信息 | 分子式 | C9H11FN2O5 | | 分子量 | 246.19 | | MDL编码 | MFCD00006530 | | Beilstein | 2645818 | | Merck | 14,4112 | | EINECS 编号 | 200-072-5 | | 存储条件 | Store at 2-8℃ |
产品描述 Floxuridine是Floxuridine的前体药物，是一种MDCK/PEPT1抑制剂，GI50为5.1 μM。 靶点（IC50 & Targe） Thymidylate synthase, 体外研究 Floxuridine呈现对PEPT1比相应的5'-O-单氨基酸酯前药更高的亲和力。[1] Floxuridine和Leucovorin联用导致人T淋巴细胞白血病细胞生长的协同抑制作用。[2] Floxuridine显著抑制(3)H-inosine和(3)H腺苷的的摄取（对照的60-70％），而它的氨基酸酯前体，包括缬氨酸，苯丙氨酸，Asp和赖氨酸酯，显著下降抑制效力（对照的10-30％）。[3] Floxuridine在36天抑制细胞增值超过对照细胞的50％，细胞数量和初始细胞密度相比增加了4倍。Floxuridine导致对体外培养的人眼球筋膜囊成纤维细胞增殖长时间延长。[4] Floxuridine是一种理想的肝动脉灌注（HAI）药物，由于其半衰期短，陡峭的剂量反应曲线，高总清除率和高肝提取。[5] 参考文献 [1] Tsume Y, et al. Mol Pharm, 2008, 5(5), 717-727. [2] Mini E, et al. Cancer Treat Rep, 1987, 71(4), 381-389. [3] Shin HC, et al. Biol Pharm Bull, 2006, 29(2), 247-252. [4] Khaw PT, et al. Arch Ophthalmol, 1992, 110(8), 1150-1154. [5] Power DG, et al. Mol Cancer Ther, 2009, 8(5), 1015-1025. 安全信息 | 图形或危害标志 | | | 提示语 | Danger | | 危险说明 | H301 | | 防范说明 | P301+P310 | | UN号码 | 2811 | | 危险分类 | 6.1 | | 包装等级 | III | | WGK | 3 | | RTECS | YU7525000 | | TSCA | 否 |
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| L16497 | Alfa Aesar | 5-Fluoro-2'-deoxyuridine | 98+% | 1740元/100mg; 6004元/500mg; | 展开 |
应用
5-Fluoro-2'-deoxyuridine acts as an antiviral and antineoplastic agent. It is also employed for renal function diagnosis. Further, it is used as an experimental anticancer agent, which shows activity against a variety of malignant neoplasms. It is also used as an inhibitor of thymidylate synthetase and DNA synthesis. In addition to this, it plays an important role in the treatment of colorectal cancer. 备注
Store in a cool place.Incompatible with strong oxidizing agents and strong bases. 基本信息 MDL
MFCD00006530 EINECS
200-072-5 分子式
C9H11FN2O5 分子量
246.20 熔点
148-151° 灵敏度
Ambient temperatures. 溶解性
Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform. Beilstein
2645818 Merck
14,4112 GHS危害和防范说明 GHS符号
  Hazard Statements
H302-H341-H360
Harmful if swallowed.Suspected of causing genetic defects.May damage fertility or the unborn child. Precautionary Statements
P201-P280-P301+P312a-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息 危险等级
6.1 包装组
III 危险类别
61-22-68
May cause harm to the unborn child.Harmful if swallowed.Possible risk of irreversible effects. 安全等级
53-20-36/37-45
Avoid exposure - obtain special instructions before use.When using do not eat or drink.Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). RTECS
YU7535000 TSCA
否 |
| F0503 | Sigma-Aldrich | 5-Fluoro-2′-deoxyuridine | thymidylate synthase inhibitor | 3044.41元/100 MG; 7325.87元/250 MG; 16465.6元/1 G; | 展开 |
产品说明 一般描述 5-氟-2′-脱氧脲核苷，也称为氟脲苷，可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌( Staphylococcus aureus)的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。 应用 5-氟-2′-脱氧脲核苷已被用作施旺(schwann)细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。 包装 100, 250 mg in poly bottle
1 g in poly bottle 生化/生理作用 一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。 基本信息 | 经验(实验)分子式 | C9H11FN2O5 | | 分子量 | 246.19 | | Beilstein | 90221 | | EC 号 | 200-072-5 | | MDL编号 | MFCD00006530 | | PubChem化学物质编号 | 24894724 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic (organic) | | 测定 | ≥99% (HPLC) | | 形式 | powder | | mp | 148 ℃ (lit.) | | 溶解性 | water: 50 mg/mL, clear, colorless to faintly yellow | | 储存温度 | room temp | | SMILES string | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O | | InChI | 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 | | InChI key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N | | Gene Information | human ... TYMS(7298)
mouse ... Tyms(22171) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P330 + P331 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
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| 1271008 | USP | Floxuridine | United States Pharmacopeia (USP) Reference Standard | 3231.47元/250 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C9H11FN2O5 | | 分子量 | 246.19 | | Beilstein | 90221 | | MDL编号 | MFCD00006530 | | PubChem化学物质编号 | 329749849 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | mp | 148 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O | | InChI | 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 | | InChI key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N | | Gene Information | human ... TYMS(7298) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P330 + P331 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| PHR2589 | Supelco | Floxuridine | pharmaceutical secondary standard, certified reference material | 2295.35元/500 MG; | 展开 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 生化/生理作用 一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 基本信息 | 经验(实验)分子式 | C9H11FN2O5 | | 分子量 | 246.19 | | Beilstein | 90221 | | MDL编号 | MFCD00006530 |
产品性质 | 等级 | certified reference material
pharmaceutical secondary standard | | 描述 | Pharmaceutical Secondary Standard; Certified Reference Material | | 形式 | powder | | CofA | current certificate can be downloaded | | 包装 | pkg of 500 mg | | mp | 148 ℃ (lit.) | | 药典可追溯性 | traceable to USP 1271008 | | 储存温度 | 2-30℃ | | SMILES string | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O | | InChI | 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 | | InChI key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P310 + P330 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 343333 | Sigma-Aldrich | 5-Fluoro-2'-deoxyuridine-CAS 50-91-9-Calbiochem | Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas. | 1940.38元/50 MG; | 展开 |
产品说明 一般描述 Experimental anti-cancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas. 生化/生理作用 Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Experimental anticancer agent 警告 Toxicity: Toxic & Carcinogenic / Teratogenic (G) 其他说明 Nakagama, H., et al. 2001. Jpn. J. Clin. Oncol.31, 251.
Malmberg, M., et al. 1993. Cell Prolif. 26, 291.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C9H11FN2O5 | | 分子量 | 246.19 | | MDL编号 | MFCD00006530 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze | | 颜色 | white | | 溶解性 | aqueous buffer: 1 mg/mL
water: 1 mg/mL | | 运输 | ambient | | 储存温度 | 2-8℃ | | InChI | 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 | | InChI key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 |
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| 009121 | Fluorochem | 2'-Deoxy-5-fluorouridine | 98% | 506元/1g; 1100元/5g; 2156元/10g; 3850元/25g; | 展开 |
基本信息 | CAS Number | 50-91-9 | | MDL Number | MFCD00006530 | | Boiling Point | 150℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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