CAS 50-65-7; 氯硝柳胺; 2',5-dichloro-4'-nitro-salicylanilid

CAS:

50-65-7

分子式:

C13H8CL2N2O4

分子量:

327.13

熔点:

225-230 °C

中文名称:

氯硝柳胺

见螺杀

血防-67

灭绦录

N-(2'-氯-4'-硝基苯)-5-氯水杨酰胺

贝螺杀

英文名称:

2',5-dichloro-4'-nitro-salicylanilid

2',5-dichlor-4'-nitro-salizylsaeureanilid

2',5-dichlor-4'-nitro-salizylsaeureanilid [german]

2-chloro-4-nitrophenylamide-6-chlorosalicylic acid

2-hydroxy-5-chloro-n-(2-chloro-4-nitrophenyl)benzamide

5-chloro-2'-chloro-4'-nitrosalicylanilide

5-chloro-n-(2'-chloro-4'-nitrophenyl)salicylamide

5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

5-chlorosalicyloyl-(o-chloro-p-nitranilide)

b 2353

bay 2353

bayer 2353

5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamid

cestocid

chemagro 2353

devermin

devermine

dichlosale

ent 25823

fedal-telmin

fenasal

helmiantin

hl 2447

iomesan

iomezan

lintex

mansonil

mato

n-(2'-chlor-4'-nitrophenyl)-5-chlorsalicylamid

n-(2-chloro-4-nitrophenyl)-5-chlorosalicylamide

nasemo

niclocide

niclosamide

nitrophenyl chlorsalicylamide

phenasal

radeverm

sagimid

sulqui

tredemine

vermitid

vermitin

wr 46234

yomesan

zestocarp

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性质描述:

淡黄色结晶。熔点225-230℃，水溶解度为5-8ppm，溶于热乙醇、环已酮、氢氧化钠液。

生产方法:

2-氯-4-硝基苯胺（见09320）与5-氯水杨酸以等摩尔比溶于二甲苯（或氯苯）中，沸腾下慢慢加入三氯化磷（或三氯氧磷），加毕，继续回流3h，冷却，滤出结晶即为氯硝柳胺。

用途:

灭钉螺药、杀软体动物剂，应用于杀灭水螺、淡水钉螺，对螺体及螺卵均有效。也可作驱绦虫药，用于驱除牛肉绦虫及猪肉绦虫。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

N796794

MACKLIN

氯硝柳胺

10mM in DMSO

265元/1ml;

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储存：-20°C

N964418

MACKLIN

氯硝柳胺

98%

30元/5g; 66元/25g; 201元/100g;

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储存：室温, 密封, 干燥
状态：白色到淡黄色固体

N814909

MACKLIN

氯硝柳胺

分析对照品

99元/25mg; 220元/100mg;

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储存：室温, 密封, 干燥
状态：白色固体

160973

J&K

Niclosamide

98%

647元/25G; 1941元/100G;

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基本信息

分子式	C₁₃H₈Cl₂N₂O₄
分子量	327.12
MDL编码	MFCD00057597
Beilstein	2820605
EINECS 编号	200-056-8

安全信息

图形或危害标志
提示语	Warning
危险说明	H400
防范说明	P273
UN号码	3077
危险分类	9
包装等级	III
WGK	2
RTECS	VN8400000

481909

Sigma-Aldrich

Niclosamide-CAS 50-65-7-Calbiochem

A salicylanilide anthelmintic drug that acts as a potent and selective Stat3- and Wnt-signaling pathway inhibitor.

717.06元/1 G;

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产品说明

一般描述

A cell-permeable salicylanilide that, in addition to its well-known antihelmintic efficacy, acts as a mammalian mTORC1, but not mTORC2, signaling inhibitor mechanistically distinct from rapamycin. Likely a direct consequence of autophagy activation, Niclosamide is demonstrated to induce Wnt-independent Frizzled1 and Dishevelled-2 downregulation. Unrelated to its autophagy induction activity, Niclosamide is also shown to inhibit Stat3 signaling (IC₅₀ = 0.25 M in HeLa reporter assays). Efficiently inhibits breast cancer stem-like cells in vitro and in vivo.
A cell-permeable salicylanilide that, in addition to its well-known antihelmintic efficacy and use in tapeworm treatment, acts as a mammalian mTORC1, but not mTORC2, signaling inhibitor mechanistically distinct from rapamycin, causing MCF-7 autophagy activation under nutrient-rich conditions (by 15-fold with 4h 10 M treatment), SH-SY5Y lysosome redistribution (10 M for 8 h), and dissipation/clearance of ubiquinated protein aggregates upon proteasome inhibition in a reversible, time- and dose-dependent manner. Likely a direct consequence of autophagy activation, Niclosamide is demonstrated to induce Wnt-independent Frizzled1 endocytosis (t_1/2 = 2.4 h; effective conc. <2 M) and Dishevelled-2 downregulation (IC₅₀ ~1 M), effectively preventing Wnt3a from stimulating HEK293 cellular LEF/TCF transcription activity (IC₅₀ = 0.5 M TOPFlash reporter assays). Unrelated to its autophagy induction activity, Niclosamide is also shown to inhibit Stat3 signaling (IC₅₀ = 0.25 M in HeLa-based pLucTKS3 reporter assays) by suppressing the phosphorylation of Jak1 Tyr1022/1023 (2 h treatment at 0.5 to 2.0 M in Du145 cultures) and Stat3 Tyr705 (by >90% after 24 h treatment at 2 and 5 M, respectively, in Du145 and HeLa cultures), without affecting the phosphorylation of Stat1 Tyr701, Stat3 Ser727, Stat5 Tyr694, or Jak2 Tyr1007/1008.

包装

1 g in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wang, Y.C., et al. 2013. PLoS ONE8, e74538.
Chen, W., et al. 2010. Am. J. Physiol. Gastrointest. Liver Physiol.299, G293.
Gies, E., et al. 2010. PLoS ONE5, e14410.
Ren, X., et al. 2010. ACS Med. Chem. Lett.1, 454.
Chen, M., et al. 2009. Biochemistry48, 10267.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₃H₈Cl₂N₂O₄
分子量	327.12
MDL编号	MFCD00057597

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	pale yellow
溶解性	DMSO: 2.5 mg/mL ethanol: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key	RJMUSRYZPJIFPJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

P-160N

AccuStandard

Niclosamide

340元/10mg;

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Niclosamide

贝螺杀氯硝柳胺

50-65-7

P-160S

AccuStandard

Niclosamide,100 μg/mL in MeOH

100 μg/mL in MeOH

340元/1mL;

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Niclosamide

贝螺杀氯硝柳胺

50-65-7

100 µg/mL

358456

Fluorochem

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

98%

286元/5g; 550元/25g; 1628元/100g;

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基本信息

CAS Number	50-65-7
MDL Number	MFCD00057597
Melting Point	225-230℃
Density	1.6646

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation. H400: Very toxic to aquatic life. H410: Very toxic to aquatic life with long lasting effects.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P273: Avoid release to the environment. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P391: Collect spillage. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .