| CAS: | 497-30-3 | ||
| 分子式: | CH15N3O2S | ||
| 分子量: | 133.20 | ||
| 熔点: | 255-259 °C | ||
| 英文名称: |
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| 性质描述: | water: 50 mg/mL, clear, colorless | ||
| 用途: | L-(+)-麦角硫因(ET)是一种含硫氨基酸，仅由担子菌科和子囊菌科的放线菌和非酵母类真菌产生。它最初是从紫麦角菌或黑麦麦角菌中分离出来的。它是从L-组氨酸中获得的，该组氨酸被转化为甜菜碱形式，称为组氨酸甜菜碱。它存在于动物和植物中，哺乳动物通常从它们的饮食中获取，例如通过蘑菇或燕麦。它的性质是互变异构的，在中性水溶液中以硫酮形式存在。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||
| L864254 | MACKLIN | 麦角硫因 | ≥98% | 40元/10mg; 79元/50mg; 242元/250mg; 720元/1g; 3026元/5g; 8210元/25g; 25200元/100g; | 展开 | ||||||||||||||||||||||||||||||||||
储存：-20°C 状态：白色粉末 物化性质：water: 50 mg/mL, clear, colorless | |||||||||||||||||||||||||||||||||||||||
| E7521 | Sigma-Aldrich | 1867.65元/5 MG; 7632.17元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 一般描述 L-(+)-Ergothioneine (ET) is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye ergot. It is obtained from L-histidine, which is converted into betaine form called hercynine. It is found in both animals and plants, and mammals usually obtain it from their diet, e.g. through mushrooms or oats. It is tautomeric in nature, and in neutral aqueous solution exists in thione form. 应用 L-(+)-Ergothioneine is suitable for use in the study of its reactivity with 2,2′- and 4,4′-dipyridyl disulphide (2-Py-S-S-2-Py and 4-Py-S-S-4-Py). It may also be used for the incubation of experimental cells while performing in vitro kinase activity assays for ATM (Ataxia telangiectasia mutated) or ATR (ATM- and RAD3-related).
生化/生理作用 L-(+)-Ergothioneine (ET) has the maximum concentrations in tissues subjected to oxidative stress, with the highest being in blood, eye lens, bone marrow, semen and liver. It acts as an anti-oxidant and prevents apoptosis, by scavenging reactive oxygen and nitrogen species. The anti-oxidant activity is attributable to sulfhydryl groups. It acts as a substrate for SLC22A4 (solute carrier family 22, member 4) transporter. In alveolar macrophages, it prevents the release of interleukin-8 (IL-8) by tumor necrosis factor (TNF)α. IL-8 is an inflammatory cytokine. It also regulates the oxidative damage in liver and kidneys, and has a protective action against lipid peroxidation. It is also responsible for the conservation of endogenous glutathione and α-tocopherol. ET being an antioxidant, protects against γ and UV radiation. In UV-irradiated human dermal fibroblasts, it scavenges reactive oxygen species (ROS), and suppresses matrix metalloproteinases 1 (MMP1) expression. It might also have anti-ageing effects on skin caused by UV-radiation. 包装 Bottomless glass bottle. Contents are inside inserted fused cone. 其他说明 Natural amino acid found in the fungus Claviceps purpurea 基本信息
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| 547179 | Fluorochem | (S)-3-(2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate | 95+% | 4928元/250mg; 12122元/1g; | 展开 | ||||||||||||||||||||||||||||||||||
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