| CAS: | 496014-13-2 | |||
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||
| 613810 | Sigma-Aldrich | TNAP Inhibitor-CAS 496014-13-2-Calbiochem | The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications. | 1954.93元/10 MG; | 咨询 | ||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable quinolinyl-benzenesulfonamide compound that acts as a potent reversible inhibitor against tissue-nonspecific (TN) alkaline phosphatase (AP) activity (IC50 = 190 nM) with CYP2C19 being the only other known target, while exhibiting little or no inhibitory activity in over 250 assays involving other enzymes, including, but not limited to, placental and intestinal APs (IC50 >100 µM), PHOSPHO1 phosphatase, and NPP1 phosphodiesterase. Kinetic studies indicate that the inhibition is uncompetitive with respect to the phosphate donor substrate and noncompetitive with respect to the acceptor substrate, indicating an allosteric inhibition mechanism. Subcutaneous dosing in rats in vivo is reported to result in plasma inhibitor concentrations in the therapeutic range (Cmax = 1.5 µg/ml 1 hr after 4.13 mg/kg by s.c.). 包装 Packaged under inert gas 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and store at (4°C). Stock solutions are stable for up to 6 months at 4°C. 其他说明 Dahl, R., et al. 2009. J. Med. Chem.52, 6919. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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