CAS 491-80-5; 5,7-二羟基-4'-甲氧基异黄酮; 5,7- dihydroxy-3-(4-methoxyphenyl)-4H-1-Benzopyran-4-one

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货号

品牌

产品名称

规格

包装、参考价格

B796899

MACKLIN

鹰嘴豆芽素A

10mM in DMSO

384元/1ml;

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储存：-20°C

B802394

MACKLIN

鹰嘴豆芽素A

98%

244元/250mg; 495元/1g; 1736元/5g; 6534元/25g;

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储存：2~8°C
状态：淡黄色粉末

B4098

TCI

Biochanin A

>98.0%(T)(HPLC)

405元/200MG; 1055元/1G; 3415元/5G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₆H₁₂O₅ = 284.27
外观与形状(20℃)	固体
包装和容器	200MG-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN	278107
PubChem物质ID	172088914
MDL编号	MFCD00006839

技术规格

Appearance	Light yellow to Yellow to Orange powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 98.0 %
Melting point	215.0 to 219.0 ℃

物性(参考值)

熔点	217 ℃
最大吸收波长	263(EtOH) nm

相关法规

RTECS#

DJ3002500

588553

J&K

Biochanin A

98%

204元/100MG; 449元/250MG;

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基本信息

分子式	C₁₆H₁₂O₅
分子量	284.26
熔点	210-213
MDL编码	MFCD00006839
Beilstein	278107
EINECS 编号	207-744-7

安全信息

防范说明	P262
WGK	3
TSCA	是

043853

Alfa Aesar

5,7-Dihydroxy-4'-methoxyisoflavone

98%

1208元/250mg; 3747元/1g; 16514元/5g;

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应用
It has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. It acts as an antineoplastic agent. It is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects. It is a nitric oxide synthase inhibitor and apoptosis inducer

备注
Store away from oxidizing agents and reducing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00006839

EINECS
207-744-7

分子式
C₁₆H₁₂O₅

分子量
284.27

熔点
210-213°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C).

Beilstein
278107

安全信息

TSCA
是

D2016

Sigma-Aldrich

Biochanin A

580.88元/100 MG; 1134.09元/250 MG; 3199.27元/1 G;

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产品说明

一般描述

鹰嘴豆芽素A(BCA)由间苯三酚在体外合成。Friedel-Crafts反应的一系列步骤得到中间产物1-(2,4,6-三羟基苯基)-2-(4甲氧基)苯基后乙酮，环化后得到BCA。摄入后被分解代谢为异黄酮染料木素。

应用

鹰嘴豆芽素 A 已被用于评估其对麦角胺(ERT)诱导的牛肠系膜脉管系统收缩力的影响。它可用于测试其在人类胶质母细胞瘤细胞系中的抗癌潜力。已在高效液相色谱-串联质谱法中采用参比标准品。

生化/生理作用

鹰嘴豆芽素 A 是在红三叶草 ( Trifolium pratense ) 中发现的一种异黄酮类植物雌激素，是ER-β雌激素受体的选择性激动剂，可能对乳腺癌有化学预防作用。与它对ER-α雌激素受体的低活性一致，它基本上没有子宫营养活性。鹰嘴豆芽素也是一种芳香烃受体(AhR)的配体。它可能通过作用于钾和/或钙离子通道，降低动脉阻力并增强微循环。诱导硫酸转移酶对外来生物的解毒作用被认为是其防癌作用的机制之一。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF D2016.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式	C₁₆H₁₂O₅
分子量	284.26
Beilstein	278107
EC 号	207-744-7
MDL编号	MFCD00006839
PubChem化学物质编号	24893597
NACRES	NA.25

产品性质

质量水平	100
mp	210-213 ℃ (lit.)
SMILES string	COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI	1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChI key	WUADCCWRTIWANL-UHFFFAOYSA-N
Gene Information	human ... CYP19A1(1588) mouse ... Aldh1a2(19378), Maoa(17161)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

92142

Supelco

Biochanin A

analytical standard

2368.6元/50 MG;

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产品说明

生化/生理作用

基本信息

经验(实验)分子式	C₁₆H₁₂O₅
分子量	284.26
Beilstein	278107
EC 号	207-744-7
MDL编号	MFCD00006839

产品性质

等级	analytical standard
质量水平	100
测定	≥95.0% (HPLC)
保质期	limited shelf life, expiry date on the label
mp	210-213 ℃ (lit.)
application(s)	food and beverages
格式	neat
SMILES string	COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI	1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChI key	WUADCCWRTIWANL-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHL80012

Biochanin A

phyproof^® Reference Substance

3001.91元/25 MG;

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产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式	C₁₆H₁₂O₅
分子量	284.26
Beilstein	278107
MDL编号	MFCD00006839

产品性质

等级	primary reference standard
产品线	phyproof^® Reference Substance
测定	≥95.0% (HPLC)
形式	powder
manufacturer/tradename	PhytoLab
mp	210-213 ℃ (lit.)
SMILES string	COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI	1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChI key	WUADCCWRTIWANL-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1071381

USP

Biochanin A

United States Pharmacopeia (USP) Reference Standard

2829.07元/20 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₂O₅
分子量	284.26
Beilstein	278107
MDL编号	MFCD00006839
PubChem化学物质编号	329749113
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	210-213 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI	1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChI key	WUADCCWRTIWANL-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

386320

Fluorochem

5,7-DIHYDROX -4'-METHOXYISOFLAVONE

95%

946元/1g; 3278元/5g; 5830元/10g;

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基本信息

CAS Number	491-80-5
MDL Number	MFCD00006839
Melting Point	217℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .