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CAS: 491-67-8
分子式: C15H10O5
分子量: 270.24
沸点: 650.2 °C at 760 mmHg
熔点: 256-271℃
中文名称: 
黄芪素
5,6,7-三羟基黄酮
黄芩素
黄芩苷元
黄芩甙元
黄芩黄素
英文名称: 
baicalein
5,6,7-Trihydroxyflavone
性质描述: 可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芩根茎
推荐供应商
货号品牌产品名称规格包装、参考价格详情
B802462MACKLIN黄芩素分析对照品, 98%87元/20mg;   展开
储存：2~8°C，避光，干燥，密封
状态：淡黄色-深黄色晶体-粉末
物化性质：可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芩根茎
折射率：1.5000
B802463MACKLIN黄芩素98%45元/100mg;   85元/1g;   138元/5g;   465元/25g;   1691元/100g;   4670元/500g;   展开
储存：2~8°C，避光，干燥，密封
状态：黄色到金色到橙色或棕色粉末或块状
物化性质：可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芩根茎
折射率：1.5000
B794555MACKLIN黄芩素10mM in DMSO339元/1ml;   展开
储存：-20°C
T2721TCIBaicalein>98.0%(T)990元/1G;   2990元/5G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C15H10O5 = 270.24
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
Reaxys-RN272683
PubChem物质ID125307744
Merck Index (14)942
MDL编号MFCD00017459

技术规格

AppearanceLight yellow to Amber to Dark green powder to crystal
Purity(HPLC)min. 95.0 area%
Purity(Neutralization titration)min. 98.0 %

物性(参考值)

熔点265 ℃
溶解性(可溶于)二甲基甲酰胺

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#DJ3100898
424823J&KBaicalein98%, 来源于黄芩66元/100MG;   196元/1G;   782元/5G;   展开

基本信息

分子式C15H10O5
分子量270.24
熔点256-271
MDL编码MFCD00017459
Beilstein272683
Merck14,942

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSDJ3100898
TSCA否
901031J&KBaicalein来源于黄芩, 有效含量≥90%, 可溯源至中检院标准品171元/20MG;   展开

基本信息

分子式C15H10O5
分子量270.24
MDL编码MFCD00017459
L14185Alfa Aesar5,6,7-Trihydroxyflavone97%721元/100mg;   2402元/500mg;   展开

基本信息

MDL
MFCD00017459

分子式
C15H10O5

分子量
270.24

熔点
268-270°

Beilstein
272683

Merck
14,942

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA
否

465119Sigma-AldrichBaicalein98%540.72元/100 MG;   2047.58元/500 MG;   展开

产品说明

一般描述

黄芩素是黄酮类化合物，是黄嘌呤氧化酶抑制剂。研究了黄芩素在人外周白细胞中的抗炎作用。

应用

黄芩素曾用于研究脂氧合酶的体外定量抑制。

包装

100, 500 mg in amber glass bottle

生化/生理作用

尼泊尔和中日天然药中的黄酮类成分。 黄芩素是黄芩的主要黄酮，可抑制花生四烯酸代谢的12-脂氧合酶(12-LOX)途径，该途径可抑制癌细胞增殖并诱导细胞凋亡。

其他说明

Scripps Center for Metabolomics(斯克里普斯代谢组学中心)独立生成的串联质谱数据，可以PDF格式查看或下载。 465119.pdf 经过测试的代谢物在Scripps Center for Metabolomics(斯克里普斯代谢组学中心) METLIN代谢物数据库有重点介绍。 更多信息请见sigma.com/metlin。

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein272683
MDL编号MFCD00017459
PubChem化学物质编号24870246
NACRESNA.22

产品性质

质量水平100
测定98%
mp256-271 ℃ (lit.)
SMILES stringOc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI keyFXNFHKRTJBSTCS-UHFFFAOYSA-N
Gene Informationmouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
92081SupelcoBaicaleinanalytical standard1880.96元/50 MG;   展开

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein272683
MDL编号MFCD00017459
NACRESNA.24

产品性质

等级analytical standard
质量水平100
测定≥95.0% (HPLC)
保质期limited shelf life, expiry date on the label
mp256-271 ℃ (lit.)
格式neat
SMILES stringOc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI keyFXNFHKRTJBSTCS-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHL89577Baicaleinphyproof® Reference Substance3110.79元/10 MG;   展开

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein272683
MDL编号MFCD00017459

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥95.0% (HPLC)
形式solid
manufacturer/tradenamePhytoLab
mp256-271 ℃ (lit.)
SMILES stringOc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI keyFXNFHKRTJBSTCS-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
196322Sigma-AldrichBaicalein-CAS 491-67-8-CalbiochemA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀= 120 nM) and reverse transcriptase.2165.23元/10 MG;   展开

产品说明

一般描述

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
12-lipoxygenase
Product does not compete with ATP.
Reversible: no
Target IC50: 120 nM against 12-lipoxygenase

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Leabeau, A., et al. 2001. Neuroreport12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H10O5
分子量270.24
MDL编号MFCD00017459

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 yellow
溶解性DMSO: 20 mg/mL
acetone: soluble
运输wet ice
储存温度−20℃
InChI1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI keyFXNFHKRTJBSTCS-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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