CAS 491-36-1; 喹唑酮-4; 4(3h)-quinazolinone

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货号

品牌

产品名称

规格

包装、参考价格

详情

H795425

MACKLIN

4-羟基喹唑啉

10mM in DMSO

185元/1ml;

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储存：-20°C

H0803

TCI

4-Hydroxyquinazoline

>98.0%(T)

290元/5G; 990元/25G;

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基本信息

纯度/分析方法	>98.0%(T)
分子式/分子量	C₈H₆N₂O = 146.15
外观与形状(20℃)	固体
Reaxys-RN	607148
PubChem物质ID	87571164
SDBS (AIST Spectral DB)	11574
MDL编号	MFCD00511302

技术规格

Appearance	White to Light yellow to Light orange powder to crystal
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	215.0 to 220.0 ℃

物性(参考值)

熔点

219 ℃

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 : 吞咽有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#

VA2300000

205437

J&K

4-Hydroxyquinazoline

98%

82元/1G; 102元/5G;

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基本信息

分子式	C₈H₆N₂O
分子量	146.15
熔点	216-219
MDL编码	MFCD00511302
Beilstein	607148
EINECS 编号	207-735-8

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
RTECS	VA2300000

A17129

Alfa Aesar

4-Hydroxyquinazoline

98%

748元/10g; 2699元/50g;

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应用
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

基本信息

MDL
MFCD00511302

EINECS
207-735-8

分子式
C₈H₆N₂O

分子量
146.15

熔点
216-219°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Beilstein
118473

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P280h-P305+P351+P338
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
VA2300000

TSCA
否

H57807

Sigma-Aldrich

4-Hydroxyquinazoline

98%

383.78元/5 G;

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基本信息

经验(实验)分子式	C₈H₆N₂O
分子量	146.15
EC 号	207-735-8
MDL编号	MFCD00511302
PubChem化学物质编号	24895709
NACRES	NA.22

产品性质

质量水平	100
测定	98%
mp	216-219 ℃ (lit.)
SMILES string	O=C1NC=Nc2ccccc12
InChI	1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChI key	QMNUDYFKZYBWQX-UHFFFAOYSA-N
Gene Information	mouse ... Parp2(11546)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

013606

Fluorochem

4-Hydroxyquinazoline

98%

220元/1g; 264元/10g; 484元/25g; 1342元/100g;

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基本信息

CAS Number	491-36-1
MDL Number	MFCD00511302
Melting Point	216 - 219 ℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .