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CAS: 473-98-3
分子式: C30H50O2
分子量: 442.72
沸点: 522.3ºC
熔点: 256-257℃
中文名称: 
白桦脂醇
英文名称: 
betulin
Lup-20(29)-ene-3β,28-diol
Betulinol
用途: 1.白桦脂醇及其衍生物作为生物制剂在HIV和癌症治疗方面表现出巨大的潜能，通过干扰病毒生命循环的后阶段来起作用的，是与病毒进入和成长成熟相关的。
2.有效的抗各种肿瘤药物，直接导致某些类型的肿瘤细胞启动自毁的细胞凋亡程序，并且可以减慢几种类型的肿瘤细胞生长。
3.可减轻膳食诱导型肥胖，降低血清和组织中的脂质含量，提高胰岛素敏感性。
4.在较高浓度下具有温和的抗炎性，而且它们的抗炎性主要归因于对非神经基因路径的抑制。
5.在体内白桦脂醇可以抑制固醇调节元件结合蛋白（SBERPs）的成熟，进而减少胆固醇和脂肪酸的生物合成。
6.此外还具有抑制头发纤维中蛋白质溶解、改善受损头发光泽、促进头发生长等活性，可应用于食品、化妆品及医药等行业。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
B886013MACKLIN桦木醇≥98%49元/1g;   115元/5g;   363元/25g;   1264元/100g;   3268元/500g;   展开
储存：2-8°C
状态：白色或灰白色粉末
折射率：1.5186
L828369MACKLIN桦木醇分析对照品110元/20mg;   展开
储存：2~8°C
状态：白色或灰白色粉末
折射率：1.5186
B794506MACKLIN桦木醇10mM in DMSO277元/1ml;   展开
储存：-20°C
B0803TCIBetulinol>97.0%(GC)420元/100MG;   展开

基本信息

纯度/分析方法>97.0%(GC)
分子式/分子量C30H50O2 = 442.73
外观与形状(20℃)固体
Reaxys-RN2064515
PubChem物质ID87563790
SDBS (AIST Spectral DB)11065
Merck Index (14)1189
MDL编号MFCD00016802

技术规格

AppearanceWhite to Light yellow powder to crystaline
Purity(GC)min. 97.0 %
Specific rotation [a]20/D+17.0 to +21.0 deg(C=2, Pyridine)

物性(参考值)

熔点253 ℃
比旋光度 [α]D19° (C=2,Pyridine)

安全信息

图形或危害标志
信号词警告
危险性说明H302 + H312 + H332 : 吞咽、皮肤接触或吸入有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P271 : 只能在室外或通风良好之处使用。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
P302 + P352 + P312 : 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。
P304 + P340 + P312 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#OK5755000
361678J&KBetulin98%347元/100MG;   1588元/1G;   展开

基本信息

分子式C30H50O2
分子量442.72
熔点256-257
比旋光度([α]20D)+19 (C=2, Pyridine)
MDL编码MFCD00016802
Beilstein2064515
Merck14,1189
EINECS 编号207-475-5
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H371
防范说明P260
WGK3
RTECSOK5755000
C46655Alfa AesarBetulin3649元/1g;   13476元/5g;   展开

基本信息

Ref#
46655

分子式
C30H50O2

B9757Sigma-AldrichBetulin≥98%2358.32元/1 G;   3333.73元/5 G;   展开

产品说明

一般描述

桦木醇是一种具有羽扇豆核的三萜类化合物 ，存在于桦树的树皮中。在酸剂存在下发生重排形成同种桦木醇。

应用

桦木醇可用于桦木酸的制备， 桦木酸具有抗 HIV、抗疟和抗炎活性。

包装

1, 5 g in poly bottle

基本信息

经验(实验)分子式C30H50O2
分子量442.72
EC 号207-475-5
MDL编号MFCD00016802
PubChem化学物质编号57653970
NACRESNA.22

产品性质

质量水平100
测定≥98%
形式powder
mp256-257 ℃ (lit.)
储存温度2-8℃
SMILES string[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]5(CO)CC[C@@H](C(C)=C)[C@]25[H]
InChI1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
InChI keyFVWJYYTZTCVBKE-ROUWMTJPSA-N

安全信息

象形图GHS08
警示用语：Warning
危险声明H371
预防措施声明P260 - P264 - P270 - P308 + P311 - P405 - P501
危险分类STOT SE 2
储存分类代码11 - Combustible Solids
WGKWGK 3
92648SupelcoBetulinanalytical standard2177.05元/50 MG;   展开

产品说明

一般描述

Betulin is a naturally occurring pentacyclic triterpene alcohol with a lupane skeleton, found in large quantities in the bark of white birch. It may possess anticancer and antiviral properties.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

基本信息

经验(实验)分子式C30H50O2
分子量442.72
EC 号207-475-5
MDL编号MFCD00016802
PubChem化学物质编号329770153
NACRESNA.24

产品性质

等级analytical standard
质量水平100
测定≥97.5% (TLC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp256-257 ℃ (lit.)
application(s)food and beverages
格式neat
SMILES string[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]5(CO)CC[C@@H](C(C)=C)[C@]25[H]
InChI1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
InChI keyFVWJYYTZTCVBKE-ROUWMTJPSA-N

安全信息

象形图GHS08
警示用语：Warning
危险声明H371
预防措施声明P260 - P264 - P270 - P308 + P311 - P405 - P501
危险分类STOT SE 2
储存分类代码11 - Combustible Solids
WGKWGK 3
PHL89581Betulinphyproof® Reference Substance3048.57元/100 MG;   展开

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式C30H50O2
分子量442.72
MDL编号MFCD00016802

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥95.0% (HPLC)
形式powder
manufacturer/tradenamePhytoLab
mp256-257 ℃ (lit.)
储存温度2-8℃
SMILES string[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]5(CO)CC[C@@H](C(C)=C)[C@]25[H]
InChI1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
InChI keyFVWJYYTZTCVBKE-ROUWMTJPSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
569371Sigma-AldrichSREBP Processing Inhibitor, Betulin-CAS 473-98-3-CalbiochemThe SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating protein). This small molecule/inhibitor is primarily us1364.79元/250 MG;   展开

产品说明

一般描述

A cell-permeable pentacyclic triterpenoid from birch bark extract that interacts with SCAP (SREBP cleavage activating protein) and prevents SREBP (sterol regulatory element-binding protein) Golgi proteolytic activation (1 to 13.55 µM in Rat hepatocytes CRL-1601) via a similar mechanism as oxysterols by inducing the association of SCAP with Insig-1 (insulin-induced gene-1), thereby causing SCAP-SREBPs complex ER retention. Unlike oxysterols, Betulin does not activate LXR to induce concomitant HMGCR (HMG-CoA reductase) degradation and SREBP-1 up-regulation. While both Betulin and HMGCR inhibitor Lovastatin (Cat. No. 438185) inhibit cellular cholesterol synthesis (by ~70% in CRL-1601 cultures with respective compound at 13.55 and 1 µM concentration), only Betulin suppresses cellular fatty acid synthesis (by ~55% at 13.55 µM in CRL-1601). Betulin is shown to exhibit comparable in vivo efficacy as Lovastatin (both dosed at 30 mg/kg/day with chow) in ameliorate high fat/cholesterol diet-induced obesity (% fat/lean tissue ratio increase from non-fat diet mice = 167, 44, and 33 in mice consuming fat diet alone, with Lovastatin, with Betulin, respectively). However, only Betulin is demonstrated to lower fasting blood glucose and insulin levels and reduce fat cell size in white adipose tissue in high fat diet mice. Fatostatin (Cat. No. 341329) in comparison does not target SCAP via sterol-binding site, nor does it induce SCAP binding to Insig-1.
A cell-permeable pentacyclic triterpenoid from birch bark extract that interacts with SCAP (SREBP cleavage activating protein) and prevents SREBP (sterol regulatory element-binding protein) Golgi proteolytic activation (1 to 13.55 µM in Rat hepatocytes CRL-1601) via a similar mechanism as oxysterols by inducing the association of SCAP with Insig-1 (insulin-induced gene-1), thereby causing SCAP-SREBPs complex ER retention. Unlike oxysterols, Betulin does not activate LXR to induce concomitant HMGCR (HMG-CoA reductase) degradation and SREBP-1 up-regulation. While both Betulin and HMGCR inhibitor Lovastatin (Cat. No. 438185) inhibit cellular cholesterol synthesis (by ~70% in CRL-1601 cultures with respective compound at 13.55 and 1 µM concentration), only Betulin suppresses cellular fatty acid synthesis (by ~55% at 13.55 µM in CRL-1601). Betulin is shown to exhibit comparable in vivo efficacy as Lovastatin (both dosed at 30 mg/kg/day with chow) in ameliorating high fat/cholesterol diet-induced obesity (% fat/lean tissue ratio increase from non-fat diet mice = 167, 44, and 33 in mice consuming fat diet alone, with Lovastatin, with Betulin, respectively). However, only Betulin is demonstrated to lower fasting blood glucose and insulin levels and reduce fat cell size in white adipose tissue in high fat diet mice. Fatostatin (Cat. No. 341329) in comparison does not target SCAP via sterol-binding site, nor does it induce SCAP binding to Insig-1.

包装

250 mg in Glass bottle

警告

Toxicity: Toxic (F)

其他说明

Tang, J.J., et al. 2011. Cell Metab.13, 44.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C30H50O2
分子量442.72
MDL编号MFCD00016802

产品性质

质量水平100
测定≥95% (NMR)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 off-white
溶解性DMSO: 3.5 mg/mL
运输wet ice
储存温度2-8℃
InChI1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
InChI keyFVWJYYTZTCVBKE-ROUWMTJPSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
547257FluorochemBetulin95%2354元/1g;   5456元/25g;   展开

基本信息

CAS Number473-98-3
CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9