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CAS: 4548-45-2
分子式: C5H3ClN2O2
分子量: 158.54
熔点: 106-110℃
中文名称: 
2-氯-5-硝基吡啶
英文名称: 
Pyridine,2-chloro-5-nitro-
2-chloro-5-nitro-pyridin
2-chloro-5-nitropyridine
性质描述: 从水中析出针状体结晶。熔点108-110℃。
生产方法: 由2-氨基吡啶经硝化、水解、氯化而得。1.硝化将浓硫酸加入反应锅,维持50℃加入2-氨基吡啶,再在50℃滴加发烟硝酸。加毕,在45℃反应2h,在室温下搅拌4h。反应液倾入碎冰中,5℃以下加氨水调节至pH为6,析出结晶。过滤、干燥,用水重结晶,得2-氨基-5-硝基吡啶。2.水解将2-氨基-5-硝基吡啶和10%氢氧化钠溶液混合,加热沸腾1h,热滤,滤液冷却,析出结晶。过滤,滤饼与水混合,加硫酸中和,过滤,干燥得2-羟基-5-硝基吡啶。3.氯化将2-羟基-5-硝基吡啶、三氯氧磷和二甲基甲酰胺混合,回流2h。冷却,倒入碎冰中析出结晶。过滤、干燥,得成品。硝化、水解、氯化的总收率约为28%。
用途: 医药中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格
C804801MACKLIN2-氯-5-硝基吡啶99%27元/5g;   61元/25g;   187元/100g;   824元/500g;   咨询
储存:室温
状态:浅黄色到黄色或棕色粉末
C0025TCI2-Chloro-5-nitropyridine>99.0%(GC)190元/5G;   490元/25G;   咨询

基本信息

纯度/分析方法>99.0%(GC)
分子式/分子量C5H3ClN2O2 = 158.54
外观与形状(20℃)固体
Reaxys-RN120453
PubChem物质ID87565234
SDBS (AIST Spectral DB)4080
MDL编号MFCD00006240

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(GC)min. 99.0 %
Melting point107.0 to 111.0 ℃

物性(参考值)

熔点110 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#US7175000
211123J&K2-Chloro-5-nitropyridine99%96元/5G;   171元/25G;   456元/100G;   咨询

基本信息

分子式C5H3ClN2O2
分子量158.54
熔点105-108
MDL编码MFCD00006240
Beilstein120453
EINECS 编号224-908-3

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSUS7175000
TSCA
A10709Alfa Aesar2-Chloro-5-nitropyridine99%1918元/25g;   4806元/100g;   咨询

应用
2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

备注
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00006240

EINECS
224-908-3

分子式
C5H3ClN2O2

分子量
158.54

熔点
104-109°

闪点
158°(316°F)

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Solubility in hot methanol. Insoluble in water.

Beilstein
120453

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P280h-P305+P351+P338
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

RTECS
US7175000

TSCA

C10974Alfa Aesar2-Chloro-5-nitropyridine99%1634元/25g;   5317元/100g;   咨询

基本信息

Ref#
10974

MDL
6240

分子式
C5 H3 Cl N2 O2

分子量
158.54

形态
Crystalline

C61801Sigma-Aldrich2-Chloro-5-nitropyridine99%555.8元/5 G;   1138.54元/25 G;   咨询

基本信息

经验(实验)分子式C5H3ClN2O2
分子量158.54
Beilstein120453
EC 号224-908-3
MDL编号MFCD00006240
PubChem化学物质编号24892844
NACRESNA.22

产品性质

质量水平100
测定99%
mp105-108 ℃ (lit.)
SMILES string[O-][N+](=O)c1ccc(Cl)nc1
InChI1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChI keyBAZVFQBTJPBRTJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
010698Fluorochem2-Chloro-5-nitropyridine98%308元/25g;   924元/100g;   咨询

基本信息

CAS Number4548-45-2
MDL NumberMFCD00006240
Melting Point106-110 ℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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