CAS 4342-03-4; 达卡巴嗪; 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamid

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货号

品牌

产品名称

规格

包装、参考价格

详情

D798107

MACKLIN

达卡巴嗪

10mM in DMSO

898元/1ml;

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储存：-20°C

D838232

MACKLIN

达卡巴嗪

98%

104元/1g; 460元/5g; 1806元/25g;

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储存：4°C
状态：白色到几乎白色粉末到晶体

D3634

TCI

Dacarbazine

>98.0%(T)(HPLC)

250元/1G; 1150元/5G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₆H₁₀N₆O = 182.19
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	光,加热
Reaxys-RN	521487
PubChem物质ID	87560054
Merck Index (14)	2798
MDL编号	MFCD00057167

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %

物性(参考值)

熔点	255 ℃(dec.)

安全信息

图形或危害标志
信号词	警告
危险性说明	H303 : 吞咽可能有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。 H351 : 怀疑致癌。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P202 : 在阅读并明了所有安全措施前切勿搬动。 P201 : 使用前取得专用说明。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P312 : 如感觉不适，呼叫急救中心/医生。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P405 : 存放处须加锁。

相关法规

RTECS#

NI3950000

308447

J&K

Dacarbazine

97.5%, 有抗黑色素瘤活性

196元/250MG; 432元/1G; 1164元/5G;

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基本信息

分子式	C₆H₁₀N₆O
分子量	182.18
MDL编码	MFCD00057167
存储条件	Store at 2-8℃

产品描述

acarbazine是三氮烯衍生物模具有抗肿瘤活性。在细胞周期的所有时期中，它烷基化DNA并与之交联，破坏DNA功能、细胞周期阻滞及凋亡；用于多种癌症治疗。

靶点（IC50 & Targe）

DNA polymerase beta

体外研究

Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway[2].

体内研究

Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice[3].

细胞实验

Cell lines: UACC903 (UACC) cells

Concentrations: 20 μM

Incubation Time: 48 h

Method:Apotosis assay: UACC903 (UACC) cells treated with or without DTIC (20 μM) for 48 h are incubated with agonist anti-Fas Ab, CH-11 (500 ng/ml), for 5 and 16 h, respectively. To distinguish whether death/apoptosis is mediated by FasR, blocking anti-Fas Ab ZB4 (2 mg/ml) is added in the corresponding groups. At the end of incubation, cells are harvested and stained with propidium iodide and FITC-annexin V (BD PharMingen) for detecting apoptosis according to the instruction provided by the company. Ten thousand cells from each group are collected, and dead and apoptotic cells are analyzed without gating using CellQuest software.

(Only for Reference)

动物实验

Animal Models: B16F1 melanoma xenograft model(C57BL/6 mice background)

Formulation: 0.9% sodium chloride

Dosages: 80 mg/kg

Administration: i.p.

(Only for Reference)

参考文献

[1] Serrone L, et al. J Exp Clin Cancer Res. 2000, 19(1):21-34.

[2] Yang S, et al. J Immunol. 2004, 172(7):4599-608.

[3] Zhang XH, et al. Oncol Lett. 2013, 6(1):69-74.

安全信息

图形或危害标志
提示语	Danger
危险说明	H302 H312 H332 H315 H319 H335 H340 H350
防范说明	P201 P261 P280 P305+P351+P338 P308+P313
WGK	3
RTECS	NI3950000

D2390

Sigma-Aldrich

Dacarbazine

antineoplastic purine analog

716.43元/100 MG; 3333.17元/1 G;

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产品说明

应用

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

包装

1 g in glass bottle
100 mg in glass bottle

生化/生理作用

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

经验(实验)分子式	C₆H₁₀N₆O
分子量	182.18
EC 号	224-396-1
MDL编号	MFCD00057167
PubChem化学物质编号	24893683
NACRES	NA.85

产品性质

质量水平	100
形式	powder or crystals
溶解性	1 M HCl: 50 mg/mL
作用机制	DNA synthesis \| interferes
抗生素抗菌谱	neoplastics
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Y0000733

Dacarbazine

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₆H₁₀N₆O
分子量	182.18
MDL编号	MFCD00057167
PubChem化学物质编号	329831122
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1924

Supelco

Dacarbazine

Pharmaceutical Secondary Standard; Certified Reference Material

1518.26元/250 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB1415 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₆H₁₀N₆O
分子量	182.18
EC 号	224-396-1
MDL编号	MFCD00057167
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
形式	powder
CofA	current certificate can be downloaded
包装	pkg of 250 mg
application(s)	pharmaceutical
药典可追溯性	traceable to BP 100 traceable to PhEur Y0000733 traceable to USP 1162308
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP100

Dacarbazine

British Pharmacopoeia (BP) Reference Standard

1706.18元/25 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₆H₁₀N₆O
分子量	182.18
EC 号	224-396-1
MDL编号	MFCD00057167
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P261 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1162308

USP

Dacarbazine

United States Pharmacopeia (USP) Reference Standard

2633.96元/125 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₆H₁₀N₆O
分子量	182.18
MDL编号	MFCD00057167
PubChem化学物质编号	329749505
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

036541

Fluorochem

4-(Dimethyltriazeno)imidazole-5-carboxamide

97%

1738元/1g; 5082元/5g;

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基本信息

CAS Number	4342-03-4
MDL Number	MFCD00057167