CAS 433249-94-6; cd40-traf6 signaling inhibitor

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CAS:

433249-94-6

分子式:

C₁₇H₁₇NO

分子量:

251.32

英文名称:

cd40-traf6 signaling inhibitor

compound 6877002

3-[(2,5-dimethylphenyl)amino]-1-phenyl-2-propen-1-one

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

D982388

MACKLIN

3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one

≥99%

447元/5mg; 1342元/25mg;

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储存：2-8°C, 密封, 干燥

SML1160

Sigma-Aldrich

CD40-TRAF6 signaling inhibitor

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

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产品说明

应用

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

包装

5, 25 mg in glass bottle

生化/生理作用

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

基本信息

经验(实验)分子式	C₁₇H₁₇NO
分子量	251.32
PubChem化学物质编号	329825690
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
InChI	1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI key	WIFPLULEUNBSTE-GZTJUZNOSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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