CAS 41639-83-2; (5z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid; latanoprost acid

CAS:

41639-83-2

分子式:

C₂₃H₃₄O₅

分子量:

390.51

中文名称:

(5z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid

英文名称:

latanoprost acid

phxa 85

(z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(3r)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

用途:

Latanoprost (free acid) is a metabolite of Latanoprost, an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. Therefore making Latanoprost (free acid) is an activator of PGF2αR.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

L864759

MACKLIN

LatanoprostAcid

98%

882元/25mg;

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储存：-20°C
状态：浅黄色液体

L1292

Sigma-Aldrich

Latanoprost acid

≥95% (HPLC)

2183.98元/1 MG; 6025.61元/5 MG;

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产品说明

包装

1, 5 mg in glass bottle
Store tightly sealed, under desiccant.

生化/生理作用

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₃H₃₄O₅
分子量	390.51
MDL编号	MFCD08056084
PubChem化学物质编号	24724524
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
颜色	pale yellow, oil
溶解性	DMSO: freely soluble methanol: soluble
创始人	Johnson & Johnson
运输	wet ice
储存温度	−20℃
SMILES string	O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc2ccccc2
InChI	1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1
InChI key	HNPFPERDNWXAGS-NFVOFSAMSA-N
Gene Information	mouse ... Ptgfr(19220)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves

Y0002205

Latanoprost impurity H

CRS European Pharmacopoeia (EP) Reference Standard

16423.3元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

包装

Store tightly sealed, under desiccant.
Unit quantity: 0.002 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₃H₃₄O₅
分子量	390.51
MDL编号	MFCD08056084

产品性质

储存温度	−20℃
SMILES string	O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc2ccccc2
InChI	1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1
InChI key	HNPFPERDNWXAGS-NFVOFSAMSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable