| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| E0858 | TCI | Etodolac | >98.0%(T)(HPLC) | 395元/5G; 1040元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C17H21NO3 = 287.36 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 应避免的情况 | 加热 | | Reaxys-RN | 928311 | | PubChem物质ID | 125307731 | | Merck Index (14) | 3874 | | MDL编号 | MFCD00133313 |
技术规格 | Appearance | White to Orange to Green powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Neutralization titration) | min. 98.0 % |
物性(参考值) 安全信息 | 图形或危害标志 |  | | 信号词 | 危险 | | 危险性说明 | H301 : 吞咽会中毒。
H319 : 造成严重眼刺激。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护眼罩/戴防护面具。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
|
相关法规 运输信息 | UN编号 | UN2811 | | 类别 | 6.1 | | 包装类别 | III | | 监管条件代码(*) | |
|
| 249233 | J&K | Etodolac | 98%, 一种COX抑制剂 | 366元/5G; 1261元/25G; | 咨询 |
基本信息 | 分子式 | C17H21NO3 | | 分子量 | 287.36 | | 熔点 | 148 | | MDL编码 | MFCD00133313 | | Beilstein | 928311 | | Merck | 14,3874 | | 存储条件 | Store at 2-8℃ |
产品描述 Etodolac 是COX抑制剂，IC50为53.5 nM。 靶点（IC50 & Targe） COX RXR-alpha 体外研究 在离体兔关节软骨细胞中，Etodolac显著抑制ICl，TNFα活化的vol，以及随后的凋亡事件例如凋亡性细胞体积减小(AVD)和caspase-3/7活性的增高。[1] 体内研究 在机械异常性疼痛的小鼠模型中，Etodolac通过COX-依赖性途径衰减paclitaxel引起的周围神经病变。[2] 在佐剂关节炎大鼠中，Etodolac和其他NSAID以剂量依赖的方式抑制足肿胀，引起胃黏膜损伤。在关节炎大鼠中，Etodolac表现出最高的UD（50）值和安全性指标。除了当其作用是由在正常大鼠中醋酸诱导的扭体评估，Etodolac表现出最高的UD（50）值和安全性指标。[3] 在佐剂关节炎大鼠中，Etodolac剂量依赖性抑制胃癌的发展，并30毫克/千克/天剂量时没有癌症检测到。在Helicobacter pylori (Hp)感染的蒙古沙鼠（MGS）的胃中，Etodolac不影响炎性细胞浸润或氧化性DNA损伤的程度，但是它显著抑制粘膜细胞的增殖并剂量依赖性抑制肠上皮组织转化的发展。[4] 在CCI大鼠中，Etodolac减轻热诱发痛觉过敏并阻断CCI侧TRAP阳性多核破骨细胞数的增加，但是，它不抑制CCI侧骨矿物质含量（BMC）和骨矿物质密度（BMD）上的的降低。[5] 参考文献 [1] Kumagai K, et al. Int J Mol Sci,?013, 14(10), 19705-19715. [2] Ito S, et al. J Pharmacol Exp Ther,?012, 342(1), 53-60. [3] Tachibana M, et al. Pharmacology,?003, 68(2), 96-104. [4] Magari H, et al. Biochem Biophys Res Commun,?005, 334(2), 606-612. [5] Suyama H, et al. Brain Res,?004, 1010(1-2), 144-150. 安全信息 | 图形或危害标志 | | | 提示语 | Danger | | 危险说明 | H301
H319 | | 防范说明 | P301+P310
P305+P351+P338 | | UN号码 | 2811 | | 危险分类 | 6.1 | | 包装等级 | III | | WGK | 3 | | RTECS | UQ0360000 |
|
| C46572 | Alfa Aesar | Etodolac | | 1317元/5g; 4175元/25g; | 咨询 |
基本信息 Ref#
46572 分子式
C17H21NO3 分子量
287.21 GHS危害和防范说明 GHS符号
Hazard Statements
H301 H319 Precautionary Statements
P264 P301+P330+P331 P405 P280 P305+P351+P338 P337+P313 安全信息 危险等级
6.1 |
| Y0000768 | | Etodolac for peak identification | European Pharmacopoeia (EP) Reference Standard | 1556.7元/0.41 mg; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。 包装 Unit quantity: 0.41 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C17H21NO3 | | 分子量 | 287.35 | | MDL编号 | MFCD00133313 | | PubChem化学物质编号 | 329831140 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 | | InChI | 1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) | | InChI key | NNYBQONXHNTVIJ-UHFFFAOYSA-N | | Gene Information | human ... PTGS2(5743) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| E2470000 | | Etodolac | European Pharmacopoeia (EP) Reference Standard | 1556.7元/60 mg; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。 包装 Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C17H21NO3 | | 分子量 | 287.35 | | MDL编号 | MFCD00133313 | | PubChem化学物质编号 | 329799029 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 | | InChI | 1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) | | InChI key | NNYBQONXHNTVIJ-UHFFFAOYSA-N | | Gene Information | human ... PTGS2(5743) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| E0516 | Sigma-Aldrich | Etodolac | | 1321.06元/10 MG; 4660.56元/50 MG; | 咨询 |
产品说明 包装 10 mg in poly bottle
50 mg in glass bottle 生化/生理作用 非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。 特点和优势 该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。 其他说明 斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF E0516.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。 基本信息 | 经验(实验)分子式 | C17H21NO3 | | 分子量 | 287.35 | | MDL编号 | MFCD00133313 | | PubChem化学物质编号 | 24278407 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 创始人 | Wyeth | | 储存温度 | 2-8℃ | | SMILES string | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 | | InChI | 1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) | | InChI key | NNYBQONXHNTVIJ-UHFFFAOYSA-N | | Gene Information | human ... PTGS1(5742), PTGS2(5743) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|
| 1268706 | USP | Etodolac | United States Pharmacopeia (USP) Reference Standard | 4457.19元/400 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C17H21NO3 | | 分子量 | 287.35 | | MDL编号 | MFCD00133313 | | PubChem化学物质编号 | 329749814 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 | | InChI | 1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) | | InChI key | NNYBQONXHNTVIJ-UHFFFAOYSA-N | | Gene Information | human ... PTGS2(5743) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| BP529 | | Etodolac | British Pharmacopoeia (BP) Reference Standard | 2667.79元/150 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。 包装 Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C17H21NO3 | | 分子量 | 287.35 | | MDL编号 | MFCD00133313 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 | | InChI | 1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) | | InChI key | NNYBQONXHNTVIJ-UHFFFAOYSA-N | | Gene Information | human ... PTGS2(5743) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| 358075 | Fluorochem | 2-(1,8-Diethyl-1H,3H,4H,9H-pyrano[3,4-b]indol-1-yl)acetic acid | 95% | 418元/1g; 814元/5g; 1628元/25g; 4620元/100g; | 咨询 |
基本信息 | CAS Number | 41340-25-4 | | MDL Number | MFCD00133313 | | Melting Point | 148℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
|
|
m.cnreagent.com