CAS 4025-59-6; 5,6-beta-epoxy-5-beta-cholestan-3-beta-o

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货号

品牌

产品名称

规格

包装、参考价格

详情

C984203

MACKLIN

Cholesterol5β,6β-epoxide

≥98%

2208元/5mg;

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储存：-20°C, 密封, 干燥

700033P

Avanti

5β,6β-epoxycholestanol

Avanti Polar Lipids

1002.37元/5 mg;

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产品说明

一般描述

5β,6β-epoxycholestanol (5β,6β-EC) is generated by cholesterol epoxidation and is a diastereoisomer of 5α,6α-epoxycholestanol (5α,6α-EC).

应用

5β,6β-epoxycholestanol may be used as a oxy-mix component in treating human colorectal adenocarcinoma CaCo-2 cells to test its effect on toll-like receptor (TLR) expression, in the preparation of langmuir monolayers for isotherm studies, as an internal standard for gas chromatography-mass spectrometry (GC–MS) chromatograms

生化/生理作用

5β,6β-epoxycholestanol (5β,6β-EC) is associated with human carotid plaques and is not down-regulated by apolipoprotein A1 (apoA-I) protein. 5,6β-EC along with 5α,6α-epoxycholesterol and other oxysterols are reported to be associated with Alzheimer′s disease. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol. 5β,6β-EC elicits cytotoxic and inflammatory properties.

包装

5 mL PTFE Vial with Screw Cap (700033P-5mg)

基本信息

经验(实验)分子式	C₂₇H₄₆O₂
分子量	402.65
NACRES	NA.25

产品性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 5 mg (700033P-5mg)
manufacturer/tradename	Avanti Polar Lipids 700033P
运输	dry ice
储存温度	−20℃
SMILES string	C[C@]12CC[C@H]([C@](CC[C@H](O)C3)(C)[C@]3(O4)[C@H]4C5)[C@@H]5[C@@H]1CC[C@@H]2[C@H](C)CCCC(C)C
InChI	1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,25-,26-,27-/m1/s1
InChI key	PRYIJAGAEJZDBO-DTLXENBRSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

C2648

Sigma-Aldrich

Cholesterol 5β,6β-epoxide

≥98%

962.2元/10 MG; 3024.94元/50 MG;

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产品说明

应用

Cholesterol 5β,6β-epoxide was used to treat PC12 cells or HepG2 and Caco-2 cells to study the effects of cholesterol oxidation.

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

Cholesterol 5β,6β-epoxide is an oxysterol produced as an oxidation product of cholesterol. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation.

基本信息

经验(实验)分子式	C₂₇H₄₆O₂
分子量	402.65
MDL编号	MFCD00201258
PubChem化学物质编号	24892511

产品性质

质量水平	100
测定	≥98%
形式	powder
官能团	epoxy
运输	ambient
储存温度	room temp
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@]3(O4)[C@H]4C2)([H])CC[C@@]5(C)[C@@]1([H])CC[C@]5([H])[C@]([H])(C)CCCC(C)C
InChI	1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3
InChI key	PRYIJAGAEJZDBO-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves