CAS 402-71-1; l-1-tosylamido-2-phenylethyl chloromethyl ketone

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

N820236

MACKLIN

N-(对甲苯磺酰基)-L-苯丙氨酰甲基氯酮

97%

60元/25mg; 139元/100mg; 346元/250mg; 1215元/1g;

展开

储存：-20°C
状态：白色-几乎白色的晶体或粉末

T2810

TCI

N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone

>95.0%(T)(HPLC)

475元/200MG; 1560元/1G;

展开

基本信息

纯度/分析方法	>95.0%(T)(HPLC)
分子式/分子量	C₁₇H₁₈ClNO₃S = 351.85
外观与形状(20℃)	固体
储存温度	<0℃
应避免的情况	加热
Reaxys-RN	2895215
PubChem物质ID	135726889
MDL编号	MFCD00000935

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 95.0 area%
Purity(Argentometric Titration)	min. 95.0 %
Melting point	106.0 to 110.0 ℃
Specific rotation [a]20/D	-87.0 to -91.0 deg(C=1, EtOH)

物性(参考值)

熔点	108 ℃
比旋光度 [α]D	-90° (C=1,EtOH)
溶解性(可溶于)	乙醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

XT5613500

C22780

Alfa Aesar

L-1-4'-Tosylamino-2-phenylethyl chloromethyl ketone

99+%

3903元/1g; 16262元/5g;

展开

基本信息

Ref#
22780

MDL
935

分子式
C17 H18 Cl N O3 S

分子量
351.84

T4376

Sigma-Aldrich

N-p-Tosyl-L-phenylalanine chloromethyl ketone

≥97% (TLC), powder

586.47元/100 MG; 858.08元/250 MG; 2636.4元/1 G; 10433.6元/5 G;

展开

产品说明

应用

使用N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮：

研究转录因子NFκB是否参与肾胺酶抗体的表达
检测NF-κB激活的作用
研究其对胰凝乳蛋白酶的抑制作用

某些丝氨酸蛋白酶的不可逆抑制剂；用于抑制胰蛋白酶制剂中的胰凝乳蛋白酶。

生化/生理作用

N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮(TPCK)可阻断脂多糖(LPS)或核因子κB (NFκB)的细胞因子诱导的激活，进而阻断诱生型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)转录的诱导。阻断所有有丝分裂原对pp70s6k的激活。通过抑制半胱天冬酶在某些细胞系和某些刺激剂中的作用，阻断凋亡细胞系。还会阻断紫杉醇中引起的细胞凋亡(MCF-7人乳腺癌细胞中)。 ′TPCK识别胰凝乳蛋白酶中的苯丙氨酸残基并阻止其功能。
阻断LPS或细胞因子诱导的核因子κB (NFκB)激活，其反过来阻断iNOS和COX-2转录的诱导。阻断所有有丝分裂原激活 pp70^s6k。通过抑制某些细胞的半胱天冬酶加工和某些刺激，进而阻断凋亡细胞。还能够阻断由紫杉醇(在MCF-7人乳腺癌细胞中)引发的细胞凋亡。

包装

无底玻璃瓶。内容物在插入式融锥内。

注意

在-20℃下干燥保存时，保质期至少为两年。

基本信息

经验(实验)分子式	C₁₇H₁₈ClNO₃S
分子量	351.85
Beilstein	2895215
EC 号	206-954-6
MDL编号	MFCD00000935
PubChem化学物质编号	24278737
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic
测定	≥97% (TLC)
形式	powder
效能	10-100 μM effective concentration
颜色	white
mp	106-108 ℃ (lit.)
溶解性	DMSO: >10 mg/mL (stable for several months at 4℃.) ethanol: 20 mg/mL (stable for several months at 4℃. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4℃.)
储存温度	−20℃
SMILES string	Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)CCl
InChI	1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1
InChI key	MQUQNUAYKLCRME-INIZCTEOSA-N
Gene Information	human ... NFKB1(4790), NKAP(79576), NKRF(55922), NOS2(4843), PTGS2(5743)

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H318 - H335
预防措施声明	P280 - P302 + P352 - P305 + P351 + P338 + P310
危险分类	Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

616387

Sigma-Aldrich

N^α-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

1164.01元/250 MG;

展开

产品说明

一般描述

This product has been discontinued.

Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC₅₀ = 20 M).
Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC₅₀ = 20 µM). Suggested working concentration is 10-100 µM.

包装

250 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
Primary Target
chymotrypsin activity in preparations
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

其他说明

Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Weaver, V.M., et al. 1993. Biochem. Cell Biol.71, 488.
Murakami, T., et al. 1991. Biochim. Biophys. Acta1079, 279.
Nierodzik, M.L., et al. 1991. J. Clin. Invest.87, 229.
Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₁₈ClNO₃S
分子量	351.85
MDL编号	MFCD00000935

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	ethanol: 5 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1
InChI key	MQUQNUAYKLCRME-INIZCTEOSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H318 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

493163

Fluorochem

Tosyl-L-Phenylalanine chloromethylketone

95%

1254元/250mg; 3168元/1g; 11220元/5g;

展开

基本信息

CAS Number	402-71-1
MDL Number	MFCD00000935
Melting Point	108℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H318: Causes serious eye damage. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a POISON CENTER or doctor/physician. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .