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CAS: 39098-97-0
分子式: C6H5ClOS
分子量: 160.62
沸点: 130-135℃
中文名称: 
噻吩-2-乙酸氯
2-噻吩乙酰氯
噻酚-2-乙酰氯
英文名称: 
thiophene-2-acetyl chloride(corrosive liquids,n.o.s.)
2-Thienylacetyl chloride
Thiophene-2-acetyl chloride
2-thiopheneacetyl chloride
2-Thiopheneacethyl chloride
性质描述: 该品沸点130-135℃(12kPa),相对密度1.303,折光率1.5504,闪点101℃。
生产方法: 由2-噻吩乙酸与氯化亚砜反应则得。将2-噻吩乙酸和氯化亚砜加入搪玻璃反应锅内,用40-50℃水浴加热反应4h,反应液进行减压蒸馏,除去剩的氯化亚砜和低沸物后,收集160℃(0.67kPa)馏分,即得2-噻吩乙酰氯。
用途: 用作医药中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格
T819206MACKLIN2-噻吩乙酰氯98%29元/5g;   63元/25g;   196元/100g;   926元/500g;   咨询
储存:2~8°C
状态:无色到淡棕色液体
折射率:n20/D 1.551(lit.)
T1751TCIThiophene-2-acetyl Chloride>98.0%(GC)(T)550元/25G;   3970元/250G;   咨询

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C6H5ClOS = 160.62
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况光,湿气 (分解)
Reaxys-RN114547
PubChem物质ID87577485
MDL编号MFCD00005456

技术规格

AppearanceYellow to Amber to Dark purple clear liquid
Purity(GC)min. 98.0 %
Purity(Argentometric Titration)min. 98.0 %

物性(参考值)

沸点106 ℃/22 mmHg
闪点85 ℃
比重1.31
折射率1.55

安全信息

图形或危害标志
信号词危险
危险性说明H314 : 造成严重皮肤灼伤和眼损伤。
H227 : 可燃液体。
H290 : 可能腐蚀金属。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P234 : 只能在原容器中存放。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P390 : 吸收溢出物,防止材料损坏。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P301 + P330 + P331 : 如误吞咽:漱口。不要诱导呕吐。
P363 : 沾染的衣服清洗后方可重新使用。
P304 + P340 + P310 : 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。立即呼叫急救中心/医生。
P305 + P351 + P338 + P310 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
P403 + P235 : 存放在通风良好的地方。保持低温。
P406 : 贮存于抗腐蚀/带抗腐蚀衬里的容器中。
P405 : 存放处须加锁。

运输信息

UN编号UN3265
类别8
包装类别 III
监管条件代码(*)
179466J&K2-Thiopheneacetyl chloride98%140元/5G;   543元/25G;   咨询

基本信息

分子式C6H5ClOS
分子量160.62
沸点105-106
密度1.304
折光率(n20D)1.5510
MDL编码MFCD00005456
Beilstein114547
EINECS 编号254-290-0
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H314
H335
防范说明P261
P280
P305+P351+P338
P310
UN号码3265
危险分类8
包装等级II
WGK3
TSCA
L09323Alfa Aesar2-Thiopheneacetyl chloride98%567元/5g;   1977元/25g;   咨询

应用
2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.

备注
Moisture Sensitive, store away from moisture. Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

基本信息

MDL
MFCD00005456

EINECS
254-290-0

分子式
C6H5ClOS

分子量
160.62

沸点
131-132°/90mm

闪点
101°(213°F)

密度
1.303

折射率
1.5513

灵敏度
Moisture Sensitive. Keep Cold.

溶解性
Reacts with water.

Beilstein
114547

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H314-H318
Harmful if swallowed.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P260h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

UN#
UN1760

危险等级
8

包装组
III

危险类别
14-22-34
Reacts violently with water.Harmful if swallowed.Causes burns.

安全等级
8-26-36/37/39-45
Keep container dry.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

欧盟危险品标志

TSCA

195995Sigma-Aldrich2-Thiopheneacetyl chloride98%729.04元/25 G;   咨询

产品说明

应用

2-Thiopheneacetyl chloride was used in the synthesis of:

  • (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
  • 5-fluorouracil-cephalosporin prodrug
  • series of new N,N′-di(thiopheneacetyl)diamines derivatives
  • 6-β-(thiophen-2′-yl)acetamidomorphine

包装

25 g in glass bottle

基本信息

经验(实验)分子式C6H5ClOS
分子量160.62
Beilstein114547
EC 号254-290-0
MDL编号MFCD00005456
PubChem化学物质编号24851729
NACRESNA.22

产品性质

质量水平200
蒸汽压4 mmHg ( 83 ℃)
测定98%
形式liquid
折射率n20/D 1.551 (lit.)
bp105-106 ℃/22 mmHg (lit.)
130-135 ℃/90 mmHg (lit.)
密度1.303 g/mL at 25 ℃ (lit.)
储存温度2-8℃
SMILES stringClC(=O)Cc1cccs1
InChI1S/C6H5ClOS/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2
InChI keyAJYXPNIENRLELY-UHFFFAOYSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H314
预防措施声明P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
危险分类Skin Corr. 1B
补充剂危害EUH014
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)215.6 °F - closed cup
闪点(C)102 ℃ - closed cup
个人防护装备Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
003050Fluorochem2-Thiopheneacetyl chloride98%220元/1g;   330元/10g;   572元/25g;   1364元/100g;   咨询

基本信息

CAS Number39098-97-0
MDL NumberMFCD00005456
Boiling Point130-135℃/90mm
Density1.303

安全信息

图形或危害标志
危险性说明 H314: Causes severe skin burns and eye damage.
防范说明 P260: Do not breathe .
P264: Wash hands thoroughly after handling.
P280: Wear .
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see . on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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