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CAS: 38748-32-2
分子式: C20H24O6
分子量: 360.40
熔点: 226-227°C
英文名称: 
8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl )-, (3bs,4as,5as,6R,6ar
,7as,7bs,8as,8bs)-
(-)-triptolide
triptolid
triptolide
推荐供应商
货号品牌产品名称规格包装、参考价格
T819207MACKLIN雷公藤甲素分析对照品,≥98%968元/20mg;   咨询
储存：2~8°C
状态：白色到灰白色固体
T794156MACKLIN雷公藤甲素10mM in DMSO390元/1ml;   咨询
储存：-20°C
状态：液体
T819208MACKLIN雷公藤甲素98%1166元/50mg;   1969元/100mg;   2550元/250mg;   8850元/1g;   咨询
储存：2~8°C
状态：白色到灰白色固体
T2899TCITriptolide>98.0%(HPLC)1180元/10MG;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)
分子式/分子量C20H24O6 = 360.41
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
包装和容器 10MG-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN1692435
PubChem物质ID172089133
Merck Index (14)9747
MDL编号MFCD00210565

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Melting point228.0 to 235.0 ℃
Specific rotation [a]20/D-165.0 to -159.0 deg(C=0.15, MeOH)

物性(参考值)

熔点229 ℃

安全信息

图形或危害标志
信号词危险
危险性说明H300 : 吞咽致命。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#YK7751000

运输信息

UN编号UN2811
类别6.1
包装类别 I
监管条件代码(*)
186866J&KTriptolide98%, 来源于雷公藤704元/10MG;   咨询

基本信息

分子式C20H24O6
分子量360.40
熔点226-227
MDL编码MFCD00210565
Merck14,9747
存储条件Store at 2-8℃

安全信息

防范说明P262
WGK3
RTECSYK7751000
C46684Alfa AesarTriptolide10377元/25mg;   23412元/100mg;   咨询

基本信息

Ref#
46684

分子式
C20H24O6

分子量
106.10

GHS危害和防范说明

GHS符号

Hazard Statements
H301
Toxic if swallowed.

Precautionary Statements
P264 P301+P330+P331 P405

645900Sigma-AldrichTriptolide, Tripterygium wilfordii-CAS 38748-32-2-CalbiochemA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.1410.99元/1 MG;   5389.51元/5 MG;   咨询

产品说明

一般描述

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Activate DEVD-cleaving caspases
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他说明

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H24O6
分子量360.40
MDL编号MFCD00210565

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 20 mg/mL
运输ambient
储存温度−20℃
InChI1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI keyDFBIRQPKNDILPW-CIVMWXNOSA-N

安全信息

象形图GHS06GHS08
警示用语：Danger
危险声明H300 + H330 - H361f
预防措施声明P201 - P202 - P260 - P264 - P270 - P304 + P340 + P310
危险分类Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
T3652Sigma-AldrichTriptolidefrom Tripterygium wilfordii, ≥98% (HPLC), solid2410.17元/1 MG;   9120.42元/5 MG;   咨询

产品说明

应用

雷公藤内酯已被用作NF-κB抑制剂，可用于研究人甲状腺癌细胞中细胞侵袭和血管生成的抑制6。雷公藤内酯也被用于研究其在间变性甲状腺癌细胞中的凋亡作用7。

包装

1, 5 mg in glass insert

生化/生理作用

雷公藤内酯是一种二萜三环氧化物，是中草药雷公藤(Tripterygium wilfordii) (TwHF)提取物中的主要活性成分 。它是一种有效的免疫抑制剂和抗炎药。雷公藤内酯已被证明在嘌呤盒/核因子和NF-κB介导的转录激活水平上抑制活化T细胞中IL-2的表达。它与环孢菌素A协同可促进动物模型中的移植物的存活，和抑制同种异体骨髓移植中的移植物抗宿主病。此外，它可诱导肿瘤细胞凋亡，并可部分通过抑制c-IAP2和c-IAP1，来增强肿瘤坏死因子(TNFα)诱导的细胞凋亡。

制备说明

雷公藤内酯可溶于DMSO中。储存溶液应在溶解后于-20℃保存在DMSO中。

基本信息

经验(实验)分子式C20H24O6
分子量360.40
MDL编号MFCD00210565
PubChem化学物质编号24900156
NACRESNA.77

产品性质

生物来源Tripterygium wilfordii
测定≥98% (HPLC)
形式solid
颜色 white to off-white
溶解性DMSO: soluble
储存温度2-8℃
SMILES stringO=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
InChI1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI keyDFBIRQPKNDILPW-KTGKZQHOSA-N

安全信息

象形图GHS06GHS08
警示用语：Danger
危险声明H300 + H330 - H361f
预防措施声明P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
危险分类Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
PHL89811Triptolidephyproof® Reference Substance6781.51元/10 MG;   咨询

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

雷公藤内酯是一种二萜三环氧化物，是中草药雷公藤(Tripterygium wilfordii) (TwHF)提取物中的主要活性成分 。它是一种有效的免疫抑制剂和抗炎药。雷公藤内酯已被证明在嘌呤盒/核因子和NF-κB介导的转录激活水平上抑制活化T细胞中IL-2的表达。它与环孢菌素A协同可促进动物模型中的移植物的存活，和抑制同种异体骨髓移植中的移植物抗宿主病。此外，它可诱导肿瘤细胞凋亡，并可部分通过抑制c-IAP2和c-IAP1，来增强肿瘤坏死因子(TNFα)诱导的细胞凋亡。

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式C20H24O6
分子量360.40
MDL编号MFCD00210565

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥98.0% (HPLC)
manufacturer/tradenamePhytoLab
application(s)food and beverages
格式neat
储存温度2-8℃
SMILES stringO=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
InChI1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI keyDFBIRQPKNDILPW-KTGKZQHOSA-N

安全信息

象形图GHS06GHS08
警示用语：Danger
危险声明H300 + H330 - H361f
预防措施声明P201 - P301 + P310 + P330 - P304 + P340 + P310
危险分类Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9