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CAS: 367-25-9
分子式: C6H5F2N
分子量: 129.11
沸点: 170℃(753
熔点: -7.5℃
中文名称: 
2,4-二氟苯胺
英文名称: 
2,4-Difluoroaniline
2,4-difluoro-anilin
2,4-difluorobenzenamine
2,4-difluoro-benzenamin
性质描述: 无色或淡黄色透明液体,遇光后呈棕色。凝固点-7.5~-7℃,沸程169-171℃,相对密度1.20-1.27,折射率1.5063,闪点62℃。不溶于水,易溶于乙醇和乙醚。
生产方法: 1.2,4-二氟硝基苯还原法将铁粉和氯化铵水溶液加入还原釜中,加热升温至回流后,滴加2,4-二氟硝基苯,加完回流2h,反应完毕,用水蒸气蒸馏,馏出液分离后,用氯化钙干燥,即可得合格产品,收率87%。2.由1,2,4-三氯苯经硝化、氟代及还原脱氯而得;或由间苯二胺经重氮化、置换、硝化、还原而得。
用途: 2,4-二氟苯胺是有机合成的中间体。医药上用于二氟苯水杨酸和多氟啶酸的合成。氟苯水杨酸是羧酸类非甾抗炎药,国际非专有药名(INN)为Diflunisal。这个水杨酸的新衍生物结构中不含有阿司匹林的乙酰基而含有二氟苯基,所以抗血小板的副作用小,且胃肠道反应轻微,作用时间可维持8-12h,可能是水杨酸类药物中最有发展前途的品种。也是农药的重要中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D828680MACKLIN2,4-二氟苯胺97%26元/25g;   45元/100g;   224元/500g;   1008元/2.5kg;   展开
储存:室温
状态:无色到棕色液体
D1508TCI2,4-Difluoroaniline>98.0%(GC)(T)320元/25G;   890元/100G;   3195元/500G;   展开

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C6H5F2N = 129.11
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN2802556
PubChem物质ID87567998
SDBS (AIST Spectral DB)16387
Merck Index (14)3147
MDL编号MFCD00007648

技术规格

AppearanceColorless to Light orange to Yellow clear liquid
Purity(GC)min. 98.0 %
Purity(Nonaqueous Titration)min. 98.0 %

物性(参考值)

沸点170 ℃
闪点62 ℃
比重1.28
折射率1.51

安全信息

图形或危害标志
信号词危险
危险性说明H311 : 皮肤接触会中毒。
H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H227 : 可燃液体。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P361 + P364 : 立即脱掉所有沾染的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P302 + P352 + P312 : 如皮肤沾染:用水充分清洗。如感觉不适,呼叫急救中心/医生。
P403 + P235 : 存放在通风良好的地方。保持低温。
P405 : 存放处须加锁。

相关法规

RTECS#BX3680000

运输信息

UN编号UN2941
类别6.1
包装类别 III
监管条件代码(*)
252316J&K2,4-Difluoroaniline99%87元/5G;   130元/25G;   356元/100G;   展开

基本信息

分子式C6H5F2N
分子量129.11
熔点-8 - -7
沸点170
闪点62
密度1.268
折光率(n20D)1.5075
MDL编码MFCD00007648
Beilstein2802556
Merck14,3147
EINECS 编号206-687-5

安全信息

图形或危害标志
提示语Danger
危险说明H302
H311
H331
防范说明P261
P280
P311
UN号码2941
危险分类6.1
包装等级III
WGK1
RTECSBX3680000
TSCA
A13673Alfa Aesar2,4-Difluoroaniline99%916元/25g;   2934元/100g;   11293元/500g;   展开

应用
2,4-Difluoroaniline is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

备注
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00007648

EINECS
206-687-5

分子式
C6H5F2N

分子量
129.11

熔点
-8° to -7°

沸点
168-170°

闪点
62°(143°F)

密度
1.281

折射率
1.5070

灵敏度
Ambient temperatures.

形态
Liquid

溶解性
Not miscible or difficult to mix.

Beilstein
2802556

Merck
14,3147

GHS危害和防范说明

GHS符号

Hazard Statements
H227-H302-H311-H331-H315-H319-H335
Combustible liquid.Harmful if swallowed.Toxic in contact with skin.Toxic if inhaled.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210e-P261-P280-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
III

危险类别
20/21/22-36/37/38
Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
9-23-26-36/37-60
Keep container in a well-ventilated place.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
BX3680000

TSCA

D101400Sigma-Aldrich2,4-Difluoroaniline99%477.97元/10 G;   718.26元/25 G;   展开

基本信息

线性分子式F2C6H3NH2
分子量129.11
Beilstein2802556
EC 号206-687-5
MDL编号MFCD00007648
PubChem化学物质编号24893321
NACRESNA.22

产品性质

质量水平200
测定99%
折射率n20/D 1.506 (lit.)
bp170 ℃/753 mmHg (lit.)
mp−7.5 ℃ (lit.)
密度1.268 g/mL at 25 ℃ (lit.)
SMILES stringNc1ccc(F)cc1F
InChI1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
InChI keyCEPCPXLLFXPZGW-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H302 - H311
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 + P312 - P361 + P364
危险分类Acute Tox. 3 Dermal - Acute Tox. 4 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 1
闪点(F)143.6 °F
闪点(C)62 ℃
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
001428Fluorochem2,4-Difluoroaniline99%264元/100g;   550元/500g;   展开

基本信息

CAS Number367-25-9
MDL NumberMFCD00007648
Boiling Point174.4℃
Density1.28

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H311: Toxic in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H331: Toxic if inhaled.
H373: May cause damage to organs ..
防范说明 P260: Do not breathe .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P311: Call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P314: Get medical advice/attention if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P361: Remove/Take off immediately all contaminated clothing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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