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CAS: 364-98-7
分子式: C8H7ClN2O2S
分子量: 230.70
中文名称: 
二氮嗪
降压嗪
氯甲苯噻嗪
7-氯-3-甲基-2氢-1,2,4-苯并噻二嗪1,1-二氧化物
英文名称: 
2h-1,2,4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
7-chloro-3-methyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido
diazossido
diazoxide
dizoxide
hyperstat
mutabase
proglicem
srg 95213
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1
Eudemine
Progylcem
展开更多英文名
性质描述: 白色或类白色结晶性粉末。熔点330-331℃。溶于乙醇,微溶于丙酮、氯仿、甲醇,不溶于水,易溶于氢氧化钠溶液。无臭,味微苦。
生产方法: 由5-氯-2-乙酰胺基-N-乙酰基苯磺酰胺经高温环合而得。环合反应在250-260℃进行,搅拌15min。然后冷却,待物料凝固后研细,用乙醇洗涤,得二氮嗪粗品。用40倍量的80%乙醇重结晶,得成品。
用途: 速效降压药。该品可使高血压患者卧、立位血压下降,为高血压危象患者急救药。临床使用时需同时使用利尿剂。充血性心力衰竭、糖尿病和肾机能不全的重型高血压患者忌用。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D859898MACKLIN氯甲苯噻嗪≥98%127元/250mg;   424元/1g;   2003元/5g;   展开
储存:室温,干燥
状态:白色到淡黄色固体
D792854MACKLIN氯甲苯噻嗪10mM in DMSO338元/1ml;   展开
储存:-20°C
D5402TCIDiazoxide>98.0%(T)(HPLC)120元/250MG;   440元/1G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C8H7ClN2O2S = 230.67
外观与形状(20℃)固体
Reaxys-RN523846
PubChem物质ID354335417
Merck Index (14)3004
MDL编号MFCD00078578

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %

物性(参考值)

熔点332 ℃
最大吸收波长268(MeOH) nm
水溶性不溶
溶解性(可溶于)二甲基甲酰胺,醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H361 : 怀疑对生育能力或胎儿造成伤害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#DK8185000
D9035Sigma-AldrichDiazoxide1255.34元/250 MG;   3053.28元/1 G;   12120.6元/5 G;   展开

产品说明

一般描述

二氮嗪是一种非利尿性苯并噻二嗪类药物,用于治疗低血糖、血管性血友病、急性和恶性高血压。作为 β 细胞 KATP 通道开放剂,二氮嗪可防止胰岛素的分泌。

应用

二氮嗪已用于二氮嗪输注。 也用于防止 K + 诱导的胞吐作用的去极化。

生化/生理作用

血管平滑肌和胰岛 β 细胞中的选择性 ATP 敏感性 K + 通道激活剂-细胞;抗高血压药。

特点和优势

该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。
该化合物出现在受体分类和信号转导手册的钾离子通道页。欲浏览其他手册页,点击此处。

基本信息

经验(实验)分子式C8H7ClN2O2S
分子量230.67
EC 号206-668-1
MDL编号MFCD00078578
PubChem化学物质编号24277831
NACRESNA.77

产品性质

质量水平100
溶解性0.1 M NaOH: soluble
H2O: insoluble
methanol: soluble
创始人Schering Plough
SMILES stringCC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InChI1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChI keyGDLBFKVLRPITMI-UHFFFAOYSA-N
Gene Informationhuman ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778)
mouse ... Kcnj1(56379), Kcnj11(16514)
rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
D0950000DiazoxideEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C8H7ClN2O2S
分子量230.67
MDL编号MFCD00078578
PubChem化学物质编号329798656
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InChI1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChI keyGDLBFKVLRPITMI-UHFFFAOYSA-N
Gene Informationhuman ... KCNJ11(3767), KCNJ8(3764)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
1186000USPDiazoxideUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C8H7ClN2O2S
分子量230.67
MDL编号MFCD00078578
PubChem化学物质编号329749368
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InChI1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChI keyGDLBFKVLRPITMI-UHFFFAOYSA-N
Gene Informationhuman ... KCNJ11(3767), KCNJ8(3764)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
047209FluorochemDiazoxide95%2508元/500mg;   4620元/1g;   13794元/5g;   48268元/25g;   展开

基本信息

CAS Number364-98-7
MDL NumberMFCD00078578

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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