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CAS: 364-62-5
分子式: C14H22ClN3O2
分子量: 299.81
熔点: 146-148°C
中文名称: 
灭吐灵
甲氧普胺
胃复安
甲氧氯普胺一盐酸盐
4-氨基-5-氯-N-[(2-二乙氨基)乙基]-2-甲氧基苯酰胺
甲氧氯普胺
4-氨基-5-氯-N-[(2-二乙氨基)乙基]-2-甲氧基苯甲酰一盐酸盐
英文名称: 
Metoclopranide
4-Amino-5-Cholo-N-[(2-diethylamino)ethyl]-2-methyloxy-benzamide
4-amino-5-chloro-n-(2-(diethylamino)ethyl)-n-anisamid
2-methoxy-5-chloroprocainamide
4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide
5-chloro-2-methoxyprocainamide
4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid
del 1267
metochlopramide
metoclol
metoclopramide
moriperan
n-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide
4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamid
plasil
primperan
reliveran
methoxychlorprocainamide
展开更多英文名
性质描述: 该品二盐酸盐一水合物([7232-21-5])熔点145℃(分解),溶于水、甲醇,稍少溶于乙醇。在酸性溶液中稳定。该品一盐酸盐一水合物([54143-57-6])为白色结晶性粉末,熔点182.5-184℃。
生产方法: 对氨基水杨酸甲酯(见02220)经酰化、醚化、氯化、胺化、水解得到灭吐灵盐基,再与氯化氢成盐得到灭吐灵(盐酸盐)。
用途: 镇吐药。本品抑制延脑催吐化学三受区的多巴胺受体。具有强大的中枢镇压吐作用,较氯丙嗪强。本品仅对药物、尿毒症和放射治疗等引起的呕吐有效。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
M814455MACKLIN胃复安98%41元/5g;   134元/25g;   440元/100g;   1698元/500g;   展开
储存:室温
M2218TCIMetoclopramide>98.0%(GC)(T)390元/5G;   1490元/25G;   展开

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C14H22ClN3O2 = 299.80
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
相关CAS RN7232-21-5
Reaxys-RN1884366
Merck Index (14)6143
MDL编号MFCD00211338

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 98.0 %
Purity(Nonaqueous Titration)min. 98.0 %
Melting point147.0 to 151.0 ℃

物性(参考值)

熔点149 ℃
水溶性不溶
在水中的溶解度0.2 g/l   25 ℃
溶解性(可溶于)甲醇
溶解性(微溶于)乙醇,丙酮

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#BZ3300000
M1824990MetoclopramideEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C14H22ClN3O2
分子量299.80
Beilstein1884366
MDL编号MFCD00211338
PubChem化学物质编号329817892
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI keyTTWJBBZEZQICBI-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR3A(3359), HTR4(3360)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
32473SupelcoMetoclopramideVETRANAL®, analytical standard1252.79元/100 MG;   展开

产品说明

一般描述

Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:

  • Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.

It may also be used as an internal standard for the determination of loratadine and desloratadine in:
  • Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.

法律信息

VETRANAL is a registered trademark of sigma-aldrich Chemie GmbH

基本信息

经验(实验)分子式C14H22ClN3O2
分子量299.80
Beilstein1884366
EC 号206-662-9
MDL编号MFCD00211338
PubChem化学物质编号329754232
NACRESNA.24

产品性质

质量水平100
等级analytical standard
产品线VETRANAL®
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI keyTTWJBBZEZQICBI-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR3A(3359), HTR4(3360)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
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