| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| A792863 | MACKLIN | 3-氨基苯甲酰胺 | 10mM in DMSO | 299元/1ml; | 咨询 |
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| A800541 | MACKLIN | 3-氨基苯甲酰胺 | 98% | 39元/1g; 102元/5g; 435元/25g; 1737元/100g; | 咨询 |
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| A0630 | TCI | 3-Aminobenzamide | >98.0%(T) | 525元/5G; 1550元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(T) | | 分子式/分子量 | C7H8N2O = 136.15 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 2802373 | | PubChem物质ID | 87562201 | | SDBS (AIST Spectral DB) | 10506 | | MDL编号 | MFCD00007989 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(Nonaqueous Titration) | min. 98.0 % | | Solubility in Methanol | almost transparency |
物性(参考值) 安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
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相关法规 |
| 161191 | J&K | 3-Aminobenzamide | 98%, 一种有效的 PARP 抑制剂,在 CHO 细胞中,对 PARP 的 IC50 值约为 50 nM | 143元/250MG; 209元/500MG; | 咨询 |
基本信息 | 分子式 | C7H8N2O | | 分子量 | 136.15 | | 熔点 | 115-116 | | MDL编码 | MFCD00007989 | | Beilstein | 2802373 | | EINECS 编号 | 222-586-9 | | 存储条件 | Freezer -20℃ |
产品描述 INO-1001是一种有效的PARP抑制剂，作用于CHO细胞的IC50为<50 nM，在再灌注期间，是一种因氧化诱导而发生的心肌功能障碍的调节剂。Phase 2 靶点（IC50 & Targe） PARP,<50nM 体外研究 用浓度为0.05 到50 μM的INO-1001处理CHO细胞30分钟，明显抑制PARP 活性， IC50 为50 nM， INO-1001浓度为1 μM 或更高时抑制PARP活性达95%，且没有细胞毒性。此外, INO-1001通过阻断大部分受辐射的DNA片段修复而使CHO 细胞敏感。[1]用400 μM H2O2处理后，通过增强乙酰胆碱诱导的, 依赖内皮细胞层的, NO调节的血管舒张，而提高INO-1001抑制PARP活性。[2] 体内研究 INO-1001作用于db/db (Leprdb/db)小鼠模型，改善 糖尿病诱导的白蛋白排泄和系膜扩张,也降低糖尿病诱导的足状突细胞耗尽。[3] INO-1001按1.6 mg/kg剂量脑内注射给药小鼠，控制皮质影响，阻止NAD+耗尽和提高水迷宫性能。[4] INO-1001作用于错配修复缺陷的移植瘤，隔离肢体灌注(ILI)之前，明显提高Temozolomide(TMZ)的有效性，且比TMZ-ILI单独出来更有效降低晚期下肢恶性黑色素瘤体积。[5] 动物实验 Animal Models: 雄性db/db(Leprdb/db)小鼠 Formulation: INO-1001溶于水中 Dosages: ≤60 mg/kg Administration: 口服处理 (Only for Reference) 参考文献 [1] Brock WA, et al. Cancer Lett. 2004, 205(2), 155-160. [2] Radovits T, et al. Eur J Pharmacol. 2007, 564(1-3), 158-166. [3] Szab?C, et al. Diabetes. 2006, 55(11), 3004-3012. [4] Clark RS, et al. J Neurotrauma. 2007, 24(8), 1399-1405. [5] Toshimitsu H, et al. Ann Surg Oncol. 2010, 17(8), 2247-2254. 安全信息 | 图形或危害标志 |  | | 提示语 | Warning | | 危险说明 | H302
H315
H319
H335 | | 防范说明 | P261
P305+P351+P338 | | UN号码 | 3077 | | 危险分类 | 9 | | 包装等级 | III | | WGK | 3 | | RTECS | CU8992000 | | TSCA | 否 |
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| A10793 | Alfa Aesar | 3-Aminobenzamide | 98% | 1176元/5g; 4597元/25g; | 咨询 |
应用
3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects. 备注
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. 基本信息 MDL
MFCD00007989 EINECS
222-586-9 分子式
C7H8N2O 分子量
136.15 熔点
111-115° 灵敏度
Ambient temperatures. 形态
Powder 溶解性
Soluble in dimethylformamide (～30 mg/ml), dimethyl sulfoxide (～30 mg/ml), phosphate buffered saline (pH7.2) (～2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml). Beilstein
2802373 GHS危害和防范说明 GHS符号
Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation. Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息 危险类别
36/37/38
Irritating to eyes, respiratory system and skin. 安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. RTECS
CU8992000 TSCA
否 |
| C33908 | Alfa Aesar | 3-Aminobenzamide | 98% | 3392元/1g; 11505元/5g; 47120元/25g; | 咨询 |
基本信息 Ref#
33908 MDL
7989 分子式
C7 H8 N2 O 分子量
136.15 |
| A0788 | Sigma-Aldrich | 3-Aminobenzamide | ≥99% (TLC) | 874.35元/100 MG; 1682.59元/250 MG; 4059.48元/1 G; 22120.5元/5 G; | 咨询 |
产品说明 应用 3-氨基苯甲酰胺已用作多种实验研究中的多聚(ADP-核糖)聚合酶(PARP)抑制剂。 包装 1, 5 g in poly bottle
100, 250 mg in poly bottle 生化/生理作用 3-氨基苯甲酰胺可干扰电离辐射和几种烷基化试剂诱发的DNA链断裂损伤修复，导致细胞死亡、程序外DNA合成和修复复制增加。它可抑制核酶多聚(ADP-核糖)合成酶(PARS)的活性。3-氨基苯甲酰胺具有抵抗心肌再灌注损伤和局部炎症的保护作用。 特点和优势 这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。 基本信息 | 线性分子式 | H2NC6H4CONH2 | | 分子量 | 136.15 | | EC 号 | 222-586-9 | | MDL编号 | MFCD00007989 | | PubChem化学物质编号 | 24278206 | | NACRES | NA.77 |
产品性质 | 测定 | ≥99% (TLC) | | 形式 | powder | | 颜色 | white to off-white | | mp | 115-116 ℃ (lit.) | | 溶解性 | ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating) | | 储存温度 | room temp | | SMILES string | NC(=O)c1cccc(N)c1 | | InChI | 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10) | | InChI key | GSCPDZHWVNUUFI-UHFFFAOYSA-N | | Gene Information | mouse ... Parp1(11545) |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 165350 | Sigma-Aldrich | PARP Inhibitor I, 3-ABA-CAS 3544-24-9-Calbiochem | The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. | 750.23元/100 MG; | 咨询 |
产品说明 一般描述 A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells. 包装 100 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
PARP 警告 Toxicity: Irritant (B) 重悬 Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C. 其他说明 Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C7H8N2O | | 分子量 | 136.15 | | MDL编号 | MFCD00007989 |
产品性质 | 质量水平 | 100 | | 测定 | ≥99% (GC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze | | 颜色 | white | | 溶解性 | ethanol: 1 mg/mL
water: 1 mg/mL
DMSO: 5 mg/mL | | 运输 | ambient | | 储存温度 | 10-30℃ | | InChI | 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10) | | InChI key | GSCPDZHWVNUUFI-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| 018167 | Fluorochem | 3-Aminobenzamide | 98% | 220元/1g; 616元/5g; 2728元/25g; 7326元/100g; | 咨询 |
基本信息 | CAS Number | 3544-24-9 | | MDL Number | MFCD00007989 | | Melting Point | 112-114℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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