| CAS: | 347323-96-0 | ||
| 分子式: | C22H17N3OS | ||
| 分子量: | 371.45 | ||
| 英文名称: |
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| 用途: | ITX3是无毒性的TrioN（N-terminal GEF domain of the multidomain Trio protein）抑制剂，IC50为76 uM，能体外抑制TrioN刺激的RhoG交换。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||
| I879442 | MACKLIN | ITX3 | 98% | 485元/5mg; 891元/10mg; | 展开 | ||||||||||||||||||||||||||||||||||||
储存：2-8℃ 状态：粉末 | |||||||||||||||||||||||||||||||||||||||||
| I1411 | Sigma-Aldrich | ITX3 | ≥98% (HPLC) | 1044.37元/5 MG; 3816.61元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs. 特点和优势 This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. 基本信息
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| 645890 | Sigma-Aldrich | Trio N-Terminal RhoGEF Domain Inhibitor, ITX3-CAS 347323-96-0-Calbiochem | The Trio N-Terminal RhoGEF Domain Inhibitor, ITX3, also referenced under CAS 347323-96-0, controls the biological activity of Trio N-Terminal RhoGEF Domain. This small molecule/inhibitor is primarily | 1954.93元/10 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable thiazolo-benzimidazolone compound that inhibits Trio N-terminal RhoGEF domain- (TrioN) mediated RhoG activation (IC50 = 76 µM) and effectively reduces cellular Rac activation (by 80% with 50 µM ITX3) caused by TrioN, but not GEF337 (RhoA GEF), Tiam1 (Rac GEF), or Vav2 (Rac1/RhoA/Cdc42 GEF), overexpression in HEK293T cells. Culture treatment of ITX at 100 µM is shown to reduce NGF-induced neurite outgrowth of rat PC12 pheochromocytoma cells by 50% and block the formation of multinucleated myotubes by 78% in C2C12 mouse myoblasts cultures induced for differentiation, while the differentiation-associated Myogenin and Troponin T expressions in Trio knock-down C2C12 cells are not affected by ITX at the same concentration. 包装 Packaged under inert gas 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Bouquier, N., et al. 2009. Chem. Biol.16, 657. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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