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DIM-C-pPhOCH3

MCE 国际站：DIM-C-pPhOCH3

品牌：MedChemExpress (MCE)

货号：HY-111492

CAS 号：33985-68-1

生物活性： DIM-C-pPhOCH3 是 Nur77 激动剂。神经生长因子诱导的 Bα (NGFI-Bα, Nur77) 是一种孤儿核受体。

体外研究(In Vitro)：DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：352.43

Formula：C24H20N2O

性状：固体

颜色：White to off-white

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：粉末 -20°C 3年

Cell Assay [1]：RKO 细胞用 DMSO 或 12.5 μM DIM-C-pPhOCH3 处理 2 和 6 小时。分离 RNA 用于逆转录 PCR (RT-PCR) 实验并分析基因表达，并为每个时间点和 DMSO 对照确定三个重复。分析微阵列数据[1]。 MCE 尚未独立确认这些方法的准确性。仅供参考。

Animal Administration [1]：Mice[1] Male athymic nude mice (Foxn1nu, ages 7-8 weeks) are used. The mice are housed and maintained in laminar flow cabinets under specific pathogen-free conditions. A xenograft is established by s.c. injection of in vitro cultured RKO cells (5×106 per 150 μL) into the flanks of individual mice. Tumors are allowed to grow for 4 days until tumors are palpable. Mice are then randomized into two groups of six mice per group and dosed by oral gavage with either corn oil or 25 mg/kg/d DIM-C-pPhOCH3 for 21 days. The mice are weighed, and tumor size is measured[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

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提供质量检测报告：Data Sheet、SDS、COA、HNMR、LCMS、产品使用指南

产品活性：DIM-C-pPhOCH3 是一种 Nur77 激动剂。Nur77 是一种孤儿核受体。

IC50 & Target：Nur77/NR4A1

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客户发表文献：
[1]. Nature. 2026 Sep;657(8131):549-558.
[2]. Nature. 2026 Sep;657(8132):755-764.
[3]. Nature. 2026 Sep;657(8133):1027-1034.
[4]. Nature. 2026 Sep;657(8131):477-486.
[5].Nature. 2026 Sep;657(8132):789-799.
[6]. Nature. 2026 Sep;657(8131):517-524.
[7]. Nature. 2026 Sep;657(8133):1045-1052.
[8]. Cell. 2026 Sep 14:S0092-8674(26)01003-2.
[9]. Cell. 2026 Sep 3;189(18):5688-5705.e13.
[10]. Cell. 2026 Sep 2:S0092-8674(26)00937-2.

参考文献：
[1]. Cho SD, et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83.