| CAS: | 336113-53-2 | |
| 分子式: | C30H33ClN4O2 | |
| 分子量: | 517.060 | |
| 英文名称: |
| |
| 用途: | Ispinesib (SB-715992)是一种有效的，特异性的，可逆kinesin spindle protein (KSP)抑制剂，无细胞试验中Kiapp为1.7 nM，对CENP-E， RabK6， MCAK， MKLP1， KHC和Kif1A没有抑制作用。Phase 2。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||
| I798063 | MACKLIN | Ispinesib (SB-715992) | 10mM in DMSO | 860元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||
| I873246 | MACKLIN | Ispinesib (SB-715992) | 99% | 80元/1mg; 190元/5mg; 329元/10mg; 1950元/100mg; | 展开 | ||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：淡-黄色固体 | |||||||||||||||||||||||||||||||||||||||||
| SML2869 | Sigma-Aldrich | Ispinesib | ≥98% (HPLC) | 833.87元/5 MG; 3365.56元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 Ispinesib (SB-715992) is a potent and highly selective kinesin spindle protein (KSP, KIF11, EG5) allosteric inhibtor that specifically inhibits microtubule (MT)-stimulated ATPase activity of KSP (Ki = 1.7 nM; 5 μM MT, 500 μM ATP, 0.75 nM human KSP), but not ubiquitous kinesin heavy chain KHC, neuronal kinesin KIF1A, or mitotic kinesins CENP-E, RabK6, MCAK, MKLP1. Ispinesib exhibits anti-cancer efficacy in cultures (GI50 = 45 nM/BT-474 & 19 nM/MDA-MB-468) and in cancer xenograft models in vivo (8 or 10 mg/kg q4d×3 ip. mice with MCF-7, HCC-1954, KPL4, BT-474 xenografts). 基本信息
产品性质
安全信息
| |||||||||||||||||||||||||||||||||||||||||
m.cnreagent.com
