CAS 3258-02-4; uridine, 4-oxime

CAS:

3258-02-4

分子式:

C₉H₁₃N₃O₆

分子量:

259.218

英文名称:

uridine, 4-oxime

4-n-hydroxycytidine

n-hydroxy-cytidin

n(4)-hydroxycytidine

n-4-hydroxycytidine

用途:

Beta-d-N4-hydroxycytidine 是一种非常有效的抗委内瑞拉马脑炎病毒剂 (anti-VEEV) ，EC50， EC90 和 EC99 分别为 0.426，1.036 和 2.5 μM。

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货号

品牌

产品名称

规格

包装、参考价格

E910610

MACKLIN

EIDD-1931(NHC)

98%

60元/5mg; 98元/10mg; 132元/50mg; 237元/250mg; 641元/1g; 2178元/5g;

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储存：-20°C，密闭，干燥
状态：白色到灰白色固体

SML2872

Sigma-Aldrich

EIDD-1931

≥98% (HPLC)

833.87元/5 MG; 3365.56元/25 MG;

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产品说明

生化/生理作用

Originally recognized as a powerful mutagen that preferentially induces AT-to-GC transition in microorganisms, EIDD-1931 (NHC, N4-hydroxycytidine) is an orally available ribonucleoside analog with known anti-viral activity against SARS-CoV, SARS-CoV-2, respiratory syncytial virus (RSV), influenza A & B viruses (IAV & IBV), HCV, pestivirus, bovine viral diarrhoea virus (BVDV), Ebola virus (EBOV), Chikungunya virus (CHIKV), venezuelan equine encephalitis virus (VEEV). NHC effectively reduces RSV and IAVs replication in mice, and exhibts efficacy in a guinea pig IAV transmission model in vivo (100 & 400 mg/kg b.i.d. p.o.). Metabolic studies reveal species-dependent plasma stability.

基本信息

经验(实验)分子式	C₉H₁₃N₃O₆
分子量	259.22

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable