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CAS: 312-84-5
分子式: C3H7NO3
分子量: 105.09
熔点: 220℃
中文名称: 
D-丝氨酸
锶胺酸
D-2-氨基-3-羟基丙酸
英文名称: 
d-serine
D-2-Amino-3-hydroxypropanoic acid
β-Hydroxyalanine
(R)-2-Amino-3-hydroxypropionic acid
H-D-Ser-OH
D-2-Amino-3-hydroxypropionic Acid
推荐供应商
货号品牌产品名称规格包装、参考价格
D794545MACKLIND-丝氨酸10mM in Water185元/1ml;   咨询
储存:-20°C
状态:白色固体
H817691MACKLIND-丝氨酸98.5%28元/5g;   38元/25g;   54元/100g;   199元/500g;   925元/2.5kg;   咨询
储存:室温
状态:白色固体
D828331MACKLIND-丝氨酸BR38元/5g;   52元/25g;   120元/100g;   咨询
储存:室温
状态:白色到灰白色粉末
S0033TCID-Serine>98.5%(T)255元/5G;   730元/25G;   咨询

基本信息

纯度/分析方法>98.5%(T)
分子式/分子量C3H7NO3 = 105.09
外观与形状(20℃)固体
Reaxys-RN1721403
PubChem物质ID87575662
SDBS (AIST Spectral DB)3927
MDL编号MFCD00004269

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(Nonaqueous Titration)min. 98.5 %
Specific rotation [a]20/D-14.3 to -15.5 deg(C=10, HCl(1+5))
Solubility in Wateralmost transparency

物性(参考值)

比旋光度 [α]D-15° (C=10,HCl(1+5))
462883J&KD-Serine98%119元/5G;   475元/25G;   1659元/100G;   咨询

基本信息

分子式C3H7NO3
分子量105.09
熔点215-225
比旋光度([α]20D)-16° to -13.5° (C=10, 2 N HCl)
MDL编码MFCD00004269
Beilstein1721403
Merck14,8460
EINECS 编号206-229-4

安全信息

防范说明P262
WGK3
RTECSVT8200000
TSCA
A11353Alfa AesarD-Serine99%536元/5g;   2168元/25g;   7763元/100g;   咨询

应用
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.

备注
Store at 4°C. Store away from oxidizing agents. Keep container closed when not in use.

基本信息

MDL
MFCD00004269

EINECS
206-229-4

分子式
C3H7NO3

分子量
105.09

熔点
218-220° dec.

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (346 mg/ml at 20°C), and mineral acids. Insoluble in alcohol, ether, and benzene.

Beilstein
1721403

Merck
14,8460

安全信息

RTECS
VT8200000

TSCA

C22707Alfa AesarD-Serine98%579元/5g;   1839元/25g;   7244元/100g;   咨询

基本信息

Ref#
22707

MDL
4269

分子式
C3 H7 N O3

分子量
105.09

S4250Sigma-AldrichD-Serine≥98% (TLC)711.79元/5 G;   2443.34元/25 G;   咨询

产品说明

一般描述

D-丝氨酸是一种在哺乳动物大脑中表达的特殊氨基酸。
D -丝氨酸是一种右旋氨基酸,存在于神经元、星形胶质细胞和小胶质细胞中。由丝氨酸消旋酶从 L -丝氨酸合成。消旋酶也可催化 D -丝氨酸分解成氨和丙酮酸。它可被 D -氨基酸氧化酶氧化为羟基丙酮酸。

应用

D-丝氨酸已被用于防止 N-甲基 D-天冬氨酸受体 (NMDAR) 的甘氨酸依赖性脱敏,并研究了其对 NMDARs 的作用,以纠正部分坐骨神经结扎 (PSNL) 后大鼠的行为异常。
D -丝氨酸已被用作人 1321N1 星形细胞瘤细胞中 D -氨基酸氧化酶 (DAO) 活性的底物。它还被用于大鼠脑室内给药以诱导抗伤害刺激效应。

包装

5, 25 g in poly bottle

生化/生理作用

D-丝氨酸是激动剂和甘氨酸模拟物,在番木鳖不敏感的甘氨酸结合位点有活性,这类结合位点与 N-甲基-D-天门冬氨酸(NMDA)受体相关,也与抑制性突触后甘氨酸受体相关。它与谷氨酸一起,在各种生理过程中起作用,这些过程包括突触可塑性和受体传递。D-丝氨酸信号传导失调与神经退行性疾病和神经失调相关。
D -丝氨酸对于树突的正常发育、成神经细胞迁移是必需的,并且可能具有精神分裂症和抑郁症治疗潜力。在创伤性脑损伤 (TBI) 中 D -丝氨酸水平升高。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDFS4250.pdf中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息,请访问sigma.com/metlin。

基本信息

经验(实验)分子式C3H7NO3
分子量105.09
Beilstein1721403
EC 号206-229-4
MDL编号MFCD00004269
PubChem化学物质编号24278008
NACRESNA.32

产品性质

质量水平200
测定≥98% (TLC)
形式powder
technique(s)ligand binding assay: suitable
颜色 white to off-white
application(s)cell analysis
SMILES stringN[C@H](CO)C(O)=O
InChI1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChI keyMTCFGRXMJLQNBG-UWTATZPHSA-N
Gene Informationhuman ... GRIN1(2902)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
011887FluorochemD-Serine95%220元/1g;   330元/25g;   660元/100g;   2640元/500g;   咨询

基本信息

CAS Number312-84-5
MDL NumberMFCD00004269

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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