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CAS: 30516-87-1
分子式: C10H13N5O4
分子量: 267.24
熔点: 113-115 °C(lit.)
中文名称: 
齐多夫定
3'-叠氮-3'-脱氧胸苷
英文名称: 
3'-azido-3'-deoxythymidine
azidothymidine
azt
bw a509u
bw-a 509u
retrovir
3'-azido-3'-deoxy-thymidin
zidovudine
azidodeoxythymidine
性质描述: 熔点106-112℃。
用途: 抗艾滋病和抗病毒原料药。
推荐供应商
货号品牌产品名称规格包装、参考价格
A795496MACKLIN3'-叠氮-3'-脱氧胸苷10mM in DMSO185元/1ml;   咨询
储存:-20°C
状态:液体
A801675MACKLIN3'-叠氮-3'-脱氧胸苷99%59元/1g;   170元/5g;   545元/25g;   1906元/100g;   咨询
储存:-20°C
状态:NA
折射率:47 ° (C=1, H2O)
A2052TCI3'-Azido-3'-deoxythymidine>98.0%(T)610元/1G;   1250元/5G;   咨询

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C10H13N5O4 = 267.25
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (吸湿)
Reaxys-RN3595791
PubChem物质ID87559740
SDBS (AIST Spectral DB)51948
Merck Index (14)10123
MDL编号MFCD00006536

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(Neutralization titration)min. 98.0 %
Melting point122.0 to 126.0 ℃
Specific rotation [a]20/D+43.0 to +51.0 deg(C=1, H2O)

物性(参考值)

熔点124 ℃
比旋光度 [α]D47° (C=1,H2O)
水溶性微溶
在水中的溶解度20 g/l   25 ℃
溶解性(可溶于)乙醇

安全信息

图形或危害标志
信号词警告
危险性说明H303 : 吞咽可能有害。
H351 : 怀疑致癌。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P312 : 如感觉不适,呼叫急救中心/医生。
P405 : 存放处须加锁。

相关法规

RTECS#XP2072000
431574J&K3'-Azido-3'-deoxythymidine(Zidovudine)98%170元/250MG;   561元/1G;   1159元/5G;   咨询

基本信息

分子式C10H13N5O4
分子量267.24
熔点113-115
MDL编码MFCD00006536
Beilstein3595791
Merck14,10123
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H351
防范说明P281
WGK3
RTECSXP2072000
PHR1292SupelcoZidovudinePharmaceutical Secondary Standard; Certified Reference Material1495.61元/1 G;   咨询

产品说明

一般描述

用于质量控制的已认证的药物二级标准,为制药实验室和制造商提供了药典基本标准的一种方便且成本效益好的替代品。
齐多夫定(AZT)是一种胸腺嘧啶核苷类似物抗HIV药物,已知可降低HIV感染患者的死亡率。其作用方式涉及到抑制病毒逆转录酶的活性并阻断HIV的复制。
用于质量控制的经认证的药物二级标准为制药实验室和制造商提供了一种方便且具有成本效益的药典主要标准替代品。

应用

齐多夫定可用作药物参考标准品,通过色谱和分光光度技术对药物制剂、片剂和药物剂型中的分析物进行测定。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

对 HIV-1 病毒有效的逆转录酶抑制剂。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

该认证参考物质(CRM)根据 ISO 17034ISO/IEC 17025 进行生产和认证。所有关于 CRM 的信息都可以在分析证书上找到。

附注

欲查看该材料的分析证书示例,请在下面的栏位中输入 LRAA0303。这只是一个示例证书,可能不是您收到的批次。

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536
PubChem化学物质编号329823283

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp113-115 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 803
traceable to PhEur Z1900000
traceable to USP 1724500
储存温度2-8℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Z1900000ZidovudineEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

对 HIV-1 病毒有效的逆转录酶抑制剂。

包装

Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536
PubChem化学物质编号329831604
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp113-115 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
A2169Sigma-Aldrich3′-Azido-3′-deoxythymidine≥98% (HPLC)1068.12元/25 MG;   3314.92元/100 MG;   4892.2元/250 MG;   14815.4元/1 G;   咨询

产品说明

应用

3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。

包装

1 g in glass bottle
25 mg in glass insert
100, 250 mg in glass bottle

生化/生理作用

叠氮胸苷 (AZT) 是一种胸苷类似物,是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536
PubChem化学物质编号24278143
NACRESNA.77

产品性质

质量水平200
测定≥98% (HPLC)
形式powder
mp113-115 ℃ (lit.)
溶解性H2O: 50 mg/mL
web metadata keyword.defaultAzidothymidine; AZT; Zidovudine, ZDV; 3′-Azido-3′-Deoxythymidine; 30516-87-1; retroviral; reverse transcriptase inhibitor; genotoxin; TK; AZTTP; AZTMP; mitochondrial dna polymerase; hypermethylation.
储存温度−20℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N
Gene Informationhuman ... HIVE1(3095)
mouse ... Slc29a1(63959)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Y0002266Zidovudine for system suitability ACRS, European Pharmacopoeia (EP) Reference Standard1341.2元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

生化/生理作用

对 HIV-1 病毒有效的逆转录酶抑制剂。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536

产品性质

manufacturer/tradenameEDQM
mp113-115 ℃ (lit.)
储存温度2-8℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1724500USPZidovudineUnited States Pharmacopeia (USP) Reference Standard3231.47元/400 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

对 HIV-1 病毒有效的逆转录酶抑制剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536
PubChem化学物质编号329751524
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp113-115 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP895Zidovudine impurity standardBritish Pharmacopoeia (BP) Reference Standard1989元/25 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

对 HIV-1 病毒有效的逆转录酶抑制剂。

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H13N5O4
分子量267.24
Beilstein3595791
MDL编号MFCD00006536

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
mp113-115 ℃ (lit.)
格式mixture
储存温度2-8℃
SMILES stringCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI keyHBOMLICNUCNMMY-XLPZGREQSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
998003Amethyst3'-Azido-3'-deoxythymidine98%, 试剂级45元/250MG;   98元/1G;   269元/5G;   572元/25G;   咨询

基本信息

分子式C10H13N5O4
分子量267.24
熔点113-115
MDL编码MFCD00006536
Beilstein3595791
Merck14,10123
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H351
防范说明P281
WGK3
RTECSXP2072000
358376Fluorochem1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione= 99% (assay)286元/1g;   704元/5g;   1958元/25g;   6160元/100g;   咨询

基本信息

CAS Number30516-87-1
MDL NumberMFCD00006536
Melting Point124℃

安全信息

图形或危害标志
危险性说明 H351: Suspected of causing cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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