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CAS: 305-01-1
分子式: C9H6O4
分子量: 178.15
熔点: 266-270℃
中文名称: 
6,7-二羟基香豆素
七叶亭
七叶停
秦皮乙素
英文名称: 
6,7-Dihydroxy-2-benzopyrone
6,7-Dihydroxycoumarin
Esculetin
6,7-dihydroxy-coumari
6,7-dihydroxy-2h-1-benzopyran-2-on
6,7-dihydroxy-2h-1-benzopyran-2-one
aesculetin
asculetine
cichorigenin
cichoriin aglycon
esculetol
esculin aglycon
Esculetine
展开更多英文名
性质描述: 白色或淡黄色针状结晶。熔点270℃。溶于乙醇和稀碱溶液,微溶于水、乙醇和乙酸乙酯,不溶于乙醚和氯仿。无臭,味微苦。
生产方法: 由苯醌经酰化、环合而得。
用途: 该品是药物平喘宁的中间体。6,7-二羟基香豆素用硫酸二甲酯甲基化,即得到平喘宁(二甲氧基香豆素)。这是一种平喘药,平喘效果明显,并有祛痰、镇咳的作用。秦皮乙素本身是一种抗菌药,对痢疾杆菌有抑制作用,可用于治疗急性菌痢,并有平喘、祛痰作用,也可用来治疗慢性气管炎。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D807649MACKLIN6,7-二羟基香豆素分析对照品190元/20mg;   展开
储存:室温
状态:黄色到黄绿色粉末
D794161MACKLIN6,7-二羟基香豆素10mM in DMSO200元/1ml;   展开
储存:-20°C
D807941MACKLIN6,7-二羟基香豆素98%29元/250mg;   35元/1g;   110元/5g;   540元/25g;   1798元/100g;   8870元/500g;   展开
储存:室温
状态:黄色到黄绿色粉末
E0386TCIEsculetin>98.0%(T)(HPLC)190元/1G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C9H6O4 = 178.14
外观与形状(20℃)固体
包装和容器 1G-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN152788
PubChem物质ID87569645
SDBS (AIST Spectral DB)23227
Merck Index (14)3697
MDL编号MFCD00006874

技术规格

AppearanceLight yellow to Brown to Dark green powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %
Solubility in hot Methanolvery faint turbidity

物性(参考值)

熔点273 ℃
最大吸收波长344(MeOH) nm
溶解性(不溶于)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#GN6382500
E1287TCIEsculetin [Matrix for MALDI-TOF/MS]>99.0%(T)(HPLC)230元/200MG;   940元/1G;   展开

基本信息

纯度/分析方法>99.0%(T)(HPLC)
分子式/分子量C9H6O4 = 178.14
外观与形状(20℃)固体
Reaxys-RN152788
SDBS (AIST Spectral DB)23227
Merck Index (14)3697
MDL编号MFCD00006874

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(HPLC)min. 99.0 area%
Purity(Neutralization titration)min. 99.0 %

物性(参考值)

熔点273 ℃
最大吸收波长344(MeOH) nm
溶解性(不溶于)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#GN6382500
564434J&KEsculetin98%418元/1G;   561元/5G;   2239元/25G;   展开

基本信息

分子式C9H6O4
分子量178.14
熔点271-273
MDL编码MFCD00006874
Beilstein152788
Merck14,3697
EINECS 编号206-161-5

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSGN6382500
941663J&KEsculetin98%418元/1G;   561元/5G;   展开

基本信息

分子式C9H6O4
分子量178.14
熔点271-273
MDL编码MFCD00006874
Beilstein152788
Merck14,3697
EINECS 编号206-161-5

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSGN6382500
A15393Alfa Aesar6,7-Dihydroxycoumarin98+%1221元/1g;   4976元/5g;   展开

应用
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

基本信息

MDL
MFCD00006874

EINECS
206-161-5

分子式
C9H6O4

分子量
178.15

熔点
ca 270° dec.

灵敏度
Keep Cold.

形态
Crystalline powder

溶解性
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Beilstein
152788

Merck
14,3697

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
GN6382500

TSCA

Y0001611EsculetinEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C9H6O4
分子量178.14
Beilstein152788
MDL编号MFCD00006874
PubChem化学物质编号329831510
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp271-273 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOc1cc2OC(=O)C=Cc2cc1O
InChI1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChI keyILEDWLMCKZNDJK-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
246573Sigma-Aldrich6,7-Dihydroxycoumarin98%1025.58元/1 G;   2437.21元/5 G;   展开

基本信息

经验(实验)分子式C9H6O4
分子量178.14
Beilstein152788
EC 号206-161-5
MDL编号MFCD00006874
PubChem化学物质编号24854815
NACRESNA.23

产品性质

质量水平100
测定98%
形式powder
mp271-273 ℃ (lit.)
SMILES stringOc1cc2OC(=O)C=Cc2cc1O
InChI1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChI keyILEDWLMCKZNDJK-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHL80449Esculetinphyproof® Reference Substance3957.46元/25 MG;   展开

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式C9H6O4
分子量178.14
Beilstein152788
MDL编号MFCD00006874

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥95.0% (HPLC)
形式powder
manufacturer/tradenamePhytoLab
mp271-273 ℃ (lit.)
SMILES stringOc1cc2OC(=O)C=Cc2cc1O
InChI1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChI keyILEDWLMCKZNDJK-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
241171Fluorochem6,7-Dihydroxy-2H-chromen-2-one95%308元/1g;   1342元/10g;   2662元/25g;   展开

基本信息

CAS Number305-01-1
MDL NumberMFCD00006874
Density1.563

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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