CAS 300802-28-2; 1,1′-[[9-(hydroxyimino)-9h-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine; ca3

CAS:

300802-28-2

分子式:

C₂₃H₂₇N₃O₅S₂

分子量:

489.61

中文名称:

1,1′-[[9-(hydroxyimino)-9h-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine

英文名称:

ca3

2,7-bis(1-piperidinylsulfonyl)-9h-fluoren-9-one oxime

cil56

用途:

CA3对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C794983

MACKLIN

CA3(CIL56)

10mM in DMSO

830元/1ml;

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储存：-20°C

C872831

MACKLIN

CA3(CIL56)

99%

810元/5mg;

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储存：-20℃
状态：粉末

SML2647

Sigma-Aldrich

CA3

≥97% (HPLC)

937.96元/5 MG; 4731.11元/25 MG;

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产品说明

生化/生理作用

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.

基本信息

经验(实验)分子式	C₂₃H₂₇N₃O₅S₂
分子量	489.61
MDL编号	MFCD00323348

产品性质

测定	≥97% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable