CAS 300657-03-8; 2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸; 2-((2'-(5-ethyl-3,4-diphenyl-1h-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

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E849033

MACKLIN

2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸

98%

399元/5mg; 1256元/25mg; 1732元/50mg; 2812元/100mg;

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储存：室温,干燥
状态：白色到灰白色固体

E794679

MACKLIN

2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸

10mM in DMSO

560元/1ml;

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储存：-20°C

341310

Sigma-Aldrich

FABP4 Inhibitor-CAS 300657-03-8-Calbiochem

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

2785.91元/5 MG;

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产品说明

一般描述

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (K_i = <2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP′s (K_i = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Furuhashi, M., et al. 2007. Nature447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃₁H₂₆N₂O₃
分子量	474.55
MDL编号	MFCD09991687

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	ethanol: 20 mg/mL DMSO: 50 mg/mL methanol: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

049791

Fluorochem

[2'-(5-ethyl-3,4-diphenyl-pyrazol-1-yl)-biphenyl-3-yloxy]acetic acid

97%

8954元/250mg; 28886元/1g;

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基本信息

CAS Number	300657-03-8
MDL Number	MFCD09991687

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .