基本信息

分子式
C17 H12 F9 N O3 S

分子量
481.33

产品说明

应用

T0901317应用于LXR激动剂研究，以观察小鼠所有受膳食胆固醇调节的基因的表达。此外，它还用于刺激WT(野生型)和Tg(转基因)小鼠放射性标记的腹腔巨噬细胞，以便进行细胞胆固醇流出测定。

生化/生理作用

T0901317能通过作用于线粒体代谢来阻止胰岛素的分泌。
LXR激动剂，其治疗导致ABC1基因表达的LXR依赖性上调

基本信息

产品性质

安全信息

产品说明

一般描述

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXR_α). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Liver X receptor (LXRα)
EC50 = 20 nM for LXRα

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Terasaka, N., et al. 2003. FEBS Lett.536, 6.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息