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CAS: 2927-71-1
分子式: C4HCl2FN2
分子量: 166.97
沸点: 80 °C / 16mmHg
熔点: 37-41 °C(lit.)
中文名称: 
2,4-二氯-5-氟嘧啶
5-氟-2,4-二氯嘧啶
英文名称: 
2,4-Dichloro-5-fluoropyrimidine
生产方法: 由5-氟脲嘧啶氯化而得。将5-氟脲嘧啶和三氯氧磷投入氯化锅,搅拌冷却至20℃以下,滴加N,N-二甲基苯胺,滴毕,缓缓升温至110℃,搅拌反应2h,冷至室温。将反应物加至饱和盐水和碎冰中冰解,温度维持15℃搅拌1h,甩滤,水洗,干燥,得成品。
用途: 抗真菌药物氟胞嘧啶的中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格
D807959MACKLIN2,4-二氯-5-氟嘧啶97%28元/1g;   29元/5g;   117元/25g;   325元/100g;   1469元/500g;   咨询
储存:室温,干燥,密封
状态:白色到棕褐色粉末,晶体和/或块状
D3374TCI2,4-Dichloro-5-fluoropyrimidine>98.0%(GC)250元/5G;   790元/25G;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C4HCl2FN2 = 166.96
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (分解)
Reaxys-RN607964
PubChem物质ID87558807

技术规格

AppearanceWhite to Almost white powder to lump
Purity(GC)min. 98.0 %
Melting point37.0 to 41.0 ℃

物性(参考值)

熔点39 ℃
沸点80 ℃/16 mmHg

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
135127J&K2,4-Dichloro-5-fluoropyrimidine98%108元/5G;   232元/25G;   700元/100G;   咨询

基本信息

分子式C4HCl2FN2
分子量166.97
熔点37-41
闪点106
MDL编码MFCD00233551

安全信息

图形或危害标志
提示语Danger
危险说明H302
H314
防范说明P280
P305+P351+P338
P310
UN号码3261
危险分类8
包装等级III
WGK3
TSCA
C44322Alfa Aesar2,4-Dichloro-5-fluoropyrimidine97%1600元/1g;   13870元/5g;   咨询

基本信息

Ref#
44322

MDL
233551

分子式
C4 H Cl2 F N2

分子量
166.97

安全信息

危险等级
8

包装组
III

653233Sigma-Aldrich2,4-Dichloro-5-fluoropyrimidine97%468.95元/1 G;   咨询

产品说明

应用

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

  • 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
  • A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
  • 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
  • 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
  • 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
  • 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

包装

1 g in glass bottle

基本信息

经验(实验)分子式C4HCl2FN2
分子量166.97
MDL编号MFCD00233551
PubChem化学物质编号24883938
NACRESNA.22

产品性质

质量水平100
测定97%
mp37-41 ℃ (lit.)
SMILES stringFc1cnc(Cl)nc1Cl
InChI1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChI keyWHPFEQUEHBULBW-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07
警示用语:Danger
危险声明H302 - H314
预防措施声明P260 - P280 - P301 + P312 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Skin Corr. 1B
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)222.8 °F - closed cup
闪点(C)106 ℃ - closed cup
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
010972Fluorochem2,4-Dichloro-5-fluoropyrimidine98%220元/1G;   770元/25g;   1650元/100g;   咨询

基本信息

CAS Number2927-71-1
MDL NumberMFCD00233551
Melting Point37-41

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H314: Causes severe skin burns and eye damage.
H317: May cause an allergic skin reaction
防范说明 P260: Do not breathe .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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