CAS 292605-14-2; sb-3ct

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货号品牌产品名称规格包装、参考价格详情
P795987MACKLINSB-3CT10mM in DMSO808元/1ml;   
储存：-20°C
P824605MACKLINSB-3CT99%79元/5mg;   314元/25mg;   979元/100mg;   
储存：2~8°C
状态：白色到浅黄色粉末
B5630TCISB-3CT>98.0%(HPLC)2690元/25MG;   7990元/100MG;   
基本信息
纯度/分析方法>98.0%(HPLC)
分子式/分子量C15H14O3S2 = 306.39
外观与形状(20℃)固体
储存温度-20℃
应避免的情况加热
Reaxys-RN8771611
MDL编号MFCD09836266
技术规格
AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 98.0   area%
物性(参考值)
熔点101 ℃
安全信息
图形或危害标志
信号词警告
危险性说明H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护眼罩/戴防护面具。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
S1326Sigma-AldrichSB-3CT≥98% (HPLC), powder3319.3元/5 MG;   13288.7元/25 MG;   
产品说明
应用
SB−3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.
包装
5, 25 mg in glass bottle
生化/生理作用
SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor.  Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and  embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).
法律信息
Sold under license of U.S. Patent 6,703,415.
基本信息
经验(实验)分子式C15H14O3S2
分子量306.40
MDL编号MFCD09836266
PubChem化学物质编号329824474
NACRESNA.77
产品性质
质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to off-white
溶解性DMSO: >20 mg/mL
储存温度−20℃
SMILES stringO=S(=O)(CC1CS1)c2ccc(Oc3ccccc3)cc2
InChI1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
InChI keyLSONWRHLFZYHIN-UHFFFAOYSA-N
安全信息
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
444274Sigma-AldrichMMP-2/MMP-9 Inhibitor IV-CAS 292605-14-2-CalbiochemThe MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applicatio2671.25元/500 μG;   
产品说明
一般描述
A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki = 206 µM) MMP-3 (Ki = 15 µM), or MMP-7 (Ki = 96 µM).
A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM), and MMP-9 (Ki = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
包装
500 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
其他说明
Krüger, A., et al. 2005. Cancer Res.65,  3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799.
法律信息
Sold under license of U.S. Patent 6,703,415.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式C15H14O3S2
分子量306.40
MDL编号MFCD09836266
产品性质
质量水平100
测定≥95% (HPLC)
形式solid
效能13.9 nM Ki
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 100 mg/mL
运输ambient
储存温度−20℃
安全信息
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable