CAS 289893-26-1; arimoclomol maleate

CAS:

289893-26-1

分子式:

C₁₈H₂₄ClN₃O₇

分子量:

429.85

英文名称:

arimoclomol maleate

brx 220

maleate salt

n-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoyl chloride 1-oxide, maleate salt

(R)-3-(chloro(2-hydroxy-3-(piperidin-1-yl)propoxyimino)methyl)pyridine 1-oxide, maleate salt

(+)-(R)-n-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride, maleate salt

brx-220

anti-neurodegeneration agent 1

brx220

用途:

Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A879788

MACKLIN

Arimoclomol maleate

≥99%

728元/5mg; 1272元/10mg;

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储存：2-8℃

SML3015

Sigma-Aldrich

Arimoclomol maleate

≥98% (HPLC)

841.96元/10 MG; 3400.25元/50 MG;

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产品说明

生化/生理作用

Arimoclomol is an orally available, CNS-penetrant coinducer of heat shock proteins (HSPs), notably HSP70, that exhibits in vivo efficay in disease models of diabetes, Gaucher disease (GD), sporadic inclusion body myositis (sIBM), and neurological disorders, including amyotrophic lateral sclerosis (ALS) and Niemann-Pick disease type C1 (NPC1). Note: arimoclomol maleate and citrate salt forms are known as BRX-220 and BRX-345, respectively.

基本信息

经验(实验)分子式	C₁₄H₂₀ClN₃O₃· C₄H₄O₄
分子量	429.85
MDL编号	MFCD28143527

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	Cl/C(C1=CC=C[N+]([O-])=C1)=N\OC[C@@H](CN2CCCCC2)O.O=C(O)/C=C\C(O)=O