CAS 289499-45-2; 卡纽替尼二盐酸盐; ci-1033

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CAS:

289499-45-2

分子式:

C₂₄H₂₇Cl₃FN₅O₃

分子量:

558.86

沸点:

691℃ at 760 mmHg

熔点:

188-190℃

中文名称:

卡纽替尼二盐酸盐

英文名称:

ci-1033

n-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

pd183805

n-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride

canertinib dihydrochloride

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C792482

MACKLIN

卡纽替尼二盐酸盐

10mM in DMSO

500元/1ml;

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储存：-20°C

C873789

MACKLIN

卡纽替尼二盐酸盐

99%

250元/10mg; 550元/50mg; 1295元/250mg; 3800元/1g;

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储存：-20℃
状态：固体

C7249

Sigma-Aldrich

CI-1033

≥98% (HPLC)

818.83元/5 MG; 3296.16元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC₅₀ in the low nanomolar range for EGFR, HER2, and ErbB-4.

特点和优势

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₂₄H₂₅ClFN₅O₃· 2HCl
分子量	558.86
MDL编号	MFCD09954112
PubChem化学物质编号	329775143
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: >10 mg/mL H₂O: >10 mg/mL
储存温度	−20℃
SMILES string	Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
InChI	1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChI key	JZZFDCXSFTVOJY-UHFFFAOYSA-N
Gene Information	human ... EGFR(1956), ERBB2(2064), ERBB4(2066)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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