CAS 287406-12-6; pf-05480090

CAS:

287406-12-6

英文名称:

pf-05480090

pf 548

way 18022

(2R,3S)-2-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)-n,3-dihydroxybutanamide

way-180022

way18022

way180022

pf5480090

tmi 2

(2R,3S)-2-[[[4-(2-butyn-1-yloxy)phenyl]sulfonyl]amino]-n,3-dihydroxybutanamide

(2R,3S)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-n,3-dihydroxybutanamide

tmi002

tmi-002

way 180022

pf05480090

pf 05480090

pf 5480090

pf-5480090

pf-548

tmi-2

way-18022

pf548

tmi2

tmi 002

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货号

品牌

产品名称

规格

包装、参考价格

详情

PZ0416

Sigma-Aldrich

PF-05480090

≥98% (HPLC)

780.67元/5 MG; 3157.38元/25 MG;

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产品说明

生化/生理作用

PF-05480090 (PF-5480090; TMI-2) is an orally active, potent TACE (ADAM17) inhibitor (IC50 = 2 nM) with good selectivity over ADAM10 (IC50 = 1.09 μM), MMP-1/7 (IC50 = 2.47/0.96 μM) and MMP-8/9/13/14 (IC50 =35/ 777/96/582 nM). TMI-2 inhibits LPS-induced TNF production in cultrues (RAW/THP-1 IC50 = 200/430 nM), ex vivo (human whole blood IC50 = 1 μM) and in vivo (ED50 = 3 mg/kg; TMI-2 p.o. 1 hr prior to 40 ng LPS/mouse i.v.). TMI-2 is efficacious in a rat model of adjuvant-induced arthritis (AIA; 30 and 100 mg/kg p.o. b.i.d.) and a murine model of collagen-induced arthritis (CIA; 100 mg/kg p.o. b.i.d.).

基本信息

经验(实验)分子式	C₁₄H₁₈N₂O₆S
分子量	342.37

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	C[C@@H]([C@H](C(NO)=O)NS(=O)(C1=CC=C(C=C1)OCC#CC)=O)O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable