CAS 287403-39-8; tmi-1

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CAS:

287403-39-8

分子式:

C₁₇H₂₂N₂O₅S₂

分子量:

398.49

英文名称:

tmi-1

way-171318

tmi 1

4-[[4-(2-butynyloxy)phenyl]sulfonyl]-n-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

T779572

MACKLIN

TMI 1

≥98%(HPLC)

1358元/5mg; 2265元/10mg;

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储存：-20°C, 密封, 干燥

PZ0336

Sigma-Aldrich

TMI-1

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

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产品说明

包装

5 mg in glass bottle

生化/生理作用

TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-α (TNF-α) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₁₇H₂₂N₂O₅S₂
分子量	398.50
PubChem化学物质编号	329823847

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 25 mg/mL, clear
创始人	Pfizer
储存温度	room temp
SMILES string	O=S(N1[C@@H](C(NO)=O)C(C)(C)SCC1)(C2=CC=C(OCC#CC)C=C2)=O
InChI	1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1
InChI key	CVZIHNYAZLXRRS-HNNXBMFYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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