CAS 28657-80-9; 3)dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1,4-dihydro-1-ethyl-4-oxo-(

CAS:

28657-80-9

分子式:

C12H10N2O5

分子量:

262.22

英文名称:

3)dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1,4-dihydro-1-ethyl-4-oxo-(

1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylic acid

1-ethyl-6,7-methylenedioxy-4(1h)-oxocinnoline-3-carboxylic acid

cinobac

cinoxacin

compound 64716

用途:

Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis through inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

C863993

MACKLIN

西诺沙星

≥99%

132元/50mg; 640元/250mg;

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储存：室温
状态：白色到灰白色粉末

C796063

MACKLIN

西诺沙星

10mM in DMSO

186元/1ml;

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储存：-20°C

R10904

Alfa Aesar

Cinoxacin Standard solution

100ppm

210元/1ml;

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安全信息

危险等级
3

C8645

Sigma-Aldrich

Cinoxacin

993.41元/1 G; 3658元/5 G;

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产品说明

一般描述

Chemical structure: quinolone

应用

Cinoxacin was used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes.

生化/生理作用

Cinoxacin is a synthetic antimicrobial agent that interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. The mechanism of action of cinoxacin is comparable to nalidixic acid. Cinoxacin is effective against Gram-negative bacteria and is often used to treat urinary tract infections caused by E. coli, Proteus mirabilis, Proteus vulgaris and Klebsiella sp.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Keep container tightly closed in a dry and well-ventilated place.

基本信息

经验(实验)分子式	C₁₂H₁₀N₂O₅
分子量	262.22
EC 号	249-133-8
MDL编号	MFCD00056776
PubChem化学物质编号	24278343
NACRES	NA.85

产品性质

质量水平	200
形式	powder or crystals
作用机制	DNA synthesis \| interferes enzyme \| inhibits
抗生素抗菌谱	Gram-negative bacteria
SMILES string	CCN1N=C(C(O)=O)C(=O)c2cc3OCOc3cc12
InChI	1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)
InChI key	VDUWPHTZYNWKRN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)