| CAS: | 285986-88-1 | |||
| 分子式: | C18H13ClF6N2O3 | |||
| 分子量: | 454.75 | |||
| 英文名称: |
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| 用途: | CCG-1423是一种新型的RhoA/C介导的基因转录抑制剂，能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||
| C794023 | MACKLIN | CCG1423 | 10mM in DMSO | 527元/1ml; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||
| C860940 | MACKLIN | CCG1423 | >98% | 124元/5mg; 205元/10mg; 498元/50mg; 1620元/250mg; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20℃ 状态：白色到米黄色粉末 折射率：white solid | |||||||||||||||||||||||||||||||||||||
| C3449 | TCI | CCG-1423 | >98.0%(GC) | 890元/25MG; 2990元/100MG; | 展开 | ||||||||||||||||||||||||||||||||
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| SML0987 | Sigma-Aldrich | CCG-1423 | ≥98% (HPLC) | 1666.25元/5 MG; 6339.56元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 CCG-1423 is a potent and specific inhibitor of Rho pathway signaling and activation of serum response factor (SRF) transcription. CCG-1423 inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active Gα13. Also CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines. 特点和优势 This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. 基本信息
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| 555558 | Sigma-Aldrich | Rho/SRF Pathway Inhibitor, CCG-1423-CAS 285986-88-1-Calbiochem | The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applicat | 2950.71元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM. 包装 25 mg in Glass bottle 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Lundquist, M.R., et al. 2014. Cell156, 563.. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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