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CAS: 2747-05-9
分子式: C12H10O4
分子量: 218.210
熔点: 152-156℃
中文名称: 
7-乙酰氧基-4-甲基香豆素
英文名称: 
4-methylumbelliferyl acetate
7-acetoxy-4-methylcoumarin
性质描述: 熔点153-155℃(99%的商品)。
生产方法: 间苯二酚经环合、乙酰化而得。在反应罐内加入乙酰乙酸乙酯和间苯二酚,搅拌升温至50℃溶解,再加入硫酸(防止冲料),加热回流1h。减压蒸干,加入乙酰乙酸乙酯,回流1h,减压蒸干。加入乙酐,回流1h。冷至80℃,缓缓加入乙醇,冷至10℃,甩滤,滤饼用乙醇洗涤至中性,干燥得7-乙酰氧基-4-甲基香豆素。熔点150-153℃(乙醇母液蒸干后可作间苯二酚投料)。
用途: 医药中间体,用于生产抗过敏药色甘酸钠。
推荐供应商
货号品牌产品名称规格包装、参考价格
A859396MACKLIN7-乙酰氧基-4-甲基香豆素>98.0%(GC)62元/1g;   194元/5g;   744元/25g;   2680元/100g;   咨询
储存:室温,干燥
状态:白色-淡黄色晶体-粉末固体
A1527TCI7-Acetoxy-4-methylcoumarin>98.0%(GC)480元/5G;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C12H10O4 = 218.21
外观与形状(20℃)固体
应避免的情况
Reaxys-RN189667
PubChem物质ID87562975
MDL编号MFCD00006865

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(GC)min. 98.0 %
Melting point151.0 to 154.0 ℃

物性(参考值)

熔点153 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
317816J&K4-Methylumbelliferyl acetate99%378元/5G;   1507元/25G;   4966元/100G;   咨询

基本信息

分子式C12H10O4
分子量218.21
熔点149-150
MDL编码MFCD00006865
Beilstein189667
EINECS 编号220-386-6
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
TSCA
M0883Sigma-Aldrich4-Methylumbelliferyl acetateesterase substrate2540.76元/5 G;   咨询

基本信息

经验(实验)分子式C12H10O4
分子量218.21
Beilstein189667
EC 号220-386-6
MDL编号MFCD00006865
PubChem化学物质编号24896576
NACRESNA.32

产品性质

质量水平100
测定≥98% (TLC)
形式powder
mp149-150 ℃ (lit.)
溶解性chloroform: 100 mg/mL, clear, colorless
荧光λex 312 nm in methanol
λex 360 nm; λem 499 nm (Reaction product)
储存温度−20℃
SMILES stringCC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1
InChI1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3
InChI keyHXVZGASCDAGAPS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
300779Fluorochem7-Acetoxy-4-methylcoumarin97%308元/1g;   704元/5g;   12980元/100g;   咨询

基本信息

CAS Number2747-05-9
MDL NumberMFCD00006865
Melting Point149-150℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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