| CAS: | 26927-01-5 | ||
| 分子式: | C26H30O5 | ||
| 分子量: | 422.51 | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||
| D937824 | MACKLIN | 7-Desacetoxy-6,7-dehydrogedunin | ≥98% | 702元/1mg; 2850元/5mg; | 展开 | ||||||||||||||||||||||||||||||||||||||
储存：2-8°C，密封，干燥 状态：固体 | |||||||||||||||||||||||||||||||||||||||||||
| SML0806 | Sigma-Aldrich | 7DG | ≥95% (HPLC) | 702.02元/1 MG; 2845.11元/5 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin. 包装 1, 5 mg in glass bottle 生化/生理作用 7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 μM, showing a role for PKR in pyroptosis. 特点和优势 This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
产品性质
安全信息
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