CAS 265646-85-3; n-(3,5-bis(trifluoromethyl)phenyl)-n′-(4-bromo-2-(1h-tetrazol-5-yl)phenyl)urea; ns3728

CAS:

265646-85-3

分子式:

C₁₆H₉BrF₆N₆O

分子量:

495.18

中文名称:

n-(3,5-bis(trifluoromethyl)phenyl)-n′-(4-bromo-2-(1h-tetrazol-5-yl)phenyl)urea

英文名称:

ns3728

endovion

ns 3728

1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1h-tetrazol-5-yl)phenyl]urea

ns-3728

用途:

Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道)，也是特异性的VRAC/VSOAC阻断剂。Endovion (NS3728)还是一种ANO1抑制剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

E879911

MACKLIN

Endovion

99%

253元/5mg; 423元/10mg; 1522元/50mg;

展开

储存：2-8℃
状态：白色到灰白色固体

SML1964

Sigma-Aldrich

NS3728

≥98% (HPLC)

1088.31元/5 MG;

展开

产品说明

生化/生理作用

NS3728 (Endovion) is a di-aryl-urea-based reversible anion channel blocker that is shown to inhibit Ca(2+)-independent Cl- conductance by volume-regulated anion channel (VRAC or VSOAC; IC50 = 400 nM) as well as Ca2+-activated Cl- ccurrent (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively). NS3728 is reported to be 5.5-times more potent than Tamoxifen against VRAC (IC50 = 0.4 vs. 2.2 μM).

基本信息

经验(实验)分子式	C₁₆H₉BrF₆N₆O
分子量	495.18
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3