基本信息

技术规格

物性(参考值)

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

基本信息

生化/生理作用

Cell permeable: no

Primary Target

Detection of proteolytic enzyme activity

Product does not compete with ATP.

Reversible: no

General description

Reagent used to prepare fluorogenic 7-amido-4-methylcoumarin (AMC) based substrates for the detection of proteolytic enzyme activity. Useful as a reference standard in enzyme assays.

Reagent used to prepare fluorogenic 7-amino-4-methylcoumarin (AMC) based substrates for the detection of proteolytic enzymes (excitation maximum: ～365-380 nm; emission maximum: ～430-460 nm). Also useful as a reference standard in enzyme assays.

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3

应用
Used as matrix for analysis of monosulfated disaccharides and as a co-matrix with 6-aza-2-thiothymidine for sulfated neutral and salivated tri-and tetrasaccharides. Reagent for preparing new fluorogenic AMC-based substrates for cystine amino peptidase (and other hydrolases). Also used as reference compound in the enzyme assay.

备注
Light Sensitive, store in dark. Store in cool, dry place in tightly closed container. Store away from oxidizing agent.

基本信息

MDL
MFCD00006868

EINECS
247-454-8

分子式
C₁₀H₉NO₂

分子量
175.19

熔点
225-228°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.

Beilstein
142231

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA
是

基本信息

Ref#
21806

MDL
6868

分子式
C10 H9 N O2

分子量
175.19

形态
Cream/pale yellow/pale brown powder

安全信息

危险等级
6.1

包装组
III

产品说明

一般描述

7-氨基-4-甲基香豆素(香豆素120)是一种氨基香豆素激光染料，可发出370-760 nm范围内的激光。它含有三个C-H···O和N-H····O分子间氢键结构。

应用

香豆素120可作为荧光标记试剂，用于痕量酶的测定。由于它可影响细胞形态，因而可用作抗结核分枝杆菌MDR分离株的抗菌剂。香豆素120也可用作电子供体(氨基)，以转移荧光传感器中的电荷，以检测水性介质中的汞离子。

包装

100, 500 mg in poly bottle

基本信息

产品性质

安全信息

产品说明

应用

用作分析单硫酸二糖的基质，并与6-氮杂-2-硫胸苷一起用作硫酸化中性糖和唾液酸化三糖和四糖的共基质。
使用7-氨基-4-甲基香豆素：

• 测定组织蛋白酶B样活性
• 作为亮氨酸氨基肽酶(LAP)的底物
• 用于糜蛋白酶测定
• 作为标准品，在人DEAD-box DDX3诱导的损伤保护过程中检测胱天蛋白酶-3的活化作用

包装

250, 500 mg in poly bottle
1 g in poly bottle

生化/生理作用

7-氨基-4-甲基香豆素是一种香豆素衍生物，可作为筛选蛋白酶抑制剂的荧光参考标准。

制备说明

可溶于二甲基亚砜(10毫克/毫升)、二甲基甲酰胺和丙酮(10毫克/毫升)。

其他说明

用于制备胱氨酸氨肽酶(和其他水解酶)的新的荧光AMC基底物的试剂；用作酶分析中的参考化合物。

基本信息

产品性质

安全信息

产品说明

一般描述

Reagent used to prepare fluorogenic 7-amino-4-methylcoumarin (AMC) based substrates for the detection of proteolytic enzymes (excitation maximum: ~365-380 nm; emission maximum: ~430-460 nm). Also useful as a reference standard in enzyme assays.
Reagent used to prepare fluorogenic 7-amido-4-methylcoumarin (AMC) based substrates for the detection of proteolytic enzyme activity. Useful as a reference standard in enzyme assays.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Detection of proteolytic enzyme activity
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). DMF and DMSO stock solutions are stable for up to 6 months at -20°C. Acetone stock solutions are stable for up to 1 week at 4°C or -20°C.

其他说明

Kanaoka, Y., et al. 1982. Chem. Pharm. Bull. 30, 1485.
Zimmerman, M., et al. 1977. Anal. Biochem. 78, 47.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

基本信息

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .