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CAS: 25812-30-0
分子式: C15H22O3
分子量: 250.35
中文名称: 
苯氧戊酸
诺衡
5-(2,5-二甲苯氧基)-2,2-二甲基戊酸
2,2-二甲基-5-(2,5-二甲基苯氧基)戊酸
吉非罗齐
英文名称: 
2,2-dimethyl-5-(2,5-xylyloxy)-valeric aci
2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
ci-719
gemfibrozil
lopid
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic aci
5-(2,5-Dimethylphenoxy)-2,2-Dimethylpentamoic Acid
2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
2,2-dimethyl-5-(2,5-dimethyl phenoxy)valeric
性质描述: 无色结晶。熔点61-63℃，沸点158-159℃（2.66×10-3kPa）。
生产方法: 1.由2,5-二甲基苯酚和溴氯丙烷反应生成1-（2,5-二甲基苯氧基）-3-氯丙烷。反应在甲苯中进行,加入新洁而灭回流反应5h。2.由异丁酸钠和异殊途同归胺锂反应生成锂代异丁酸。3.由1-（2,5-二甲基苯氧基）-3-氯丙烷和锂代异丁酸合成苯氧戊酸。将这两种中间体在10-15℃缓缓混合，搅拌15min。然后升温至30℃，保温反应5h。
用途: 该品为苯氧芳酸类降血脂药。苯氧芳酸类降血脂药是在安妥明的基础上发展起来。包括非诺贝特。脂益多，必降酯，苯氧戊酸等。这类药物在化学结构上有类似之处。安妥明不良反应较严重（有胆石发生率增高现象），经过改进的品种，作用较安妥明强，不良反应较少而且较轻。
推荐供应商
货号品牌产品名称规格包装、参考价格
G795424MACKLIN吉非罗齐10mM in DMSO425元/1ml;   咨询
储存：-20°C
G0368TCIGemfibrozil>98.0%(GC)(T)600元/5G;   1560元/25G;   咨询

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C15H22O3 = 250.34
外观与形状(20℃)固体
Reaxys-RN1881200
PubChem物质ID125307848
SDBS (AIST Spectral DB)52970
Merck Index (14)4388
MDL编号MFCD00079335

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 98.0 %
Purity(Neutralization titration)min. 98.0 %
Melting point59.0 to 63.0 ℃

物性(参考值)

熔点61 ℃
沸点159 ℃/0.02 mmHg
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H413 : 可能对水生生物造成长期持续有害影响。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P273 : 避免释放到环境中。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#YV7120000
C46179Alfa AesarGemfibrozil98%1185元/5g;   4695元/25g;   咨询

基本信息

Ref#
46179

分子式
C15H22O3

分子量
259.30

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P301+P330+P331 P312 P264

G9518Sigma-AldrichGemfibrozil1142.25元/5 G;   3677.82元/25 G;   咨询

产品说明

一般描述

吉非罗齐是一种纤维酸衍生物和降血脂药。吉非罗齐可作为 PPARα(过氧化物酶体增殖物激活受体 α)的配体。

应用

吉非罗齐已被用于研究其对酵母细胞周期进程的影响。它已被用于研究贝特类药物对人细胞系中细胞增殖和基因表达的影响。

生化/生理作用

吉非罗齐选择性增加载脂蛋白 A-I 水平。在酵母细胞中，吉非罗齐的应用会延迟 DNA 复制的开始。它被用作血脂异常的治疗药物。

特点和优势

该化合物由Pfizer开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDFG9518.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式C15H22O3
分子量250.33
EC 号247-280-2
MDL编号MFCD00079335
PubChem化学物质编号24895377
NACRESNA.77

产品性质

形式powder
质量水平100
创始人Pfizer
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 + P330 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHR1286SupelcoGemfibrozilPharmaceutical Secondary Standard; Certified Reference Material855.65元/1 G;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Gemfibrozil is a cholesterol-lowering drug that effectively lowers the serum cholesterol, triglyceride, and low-density lipoprotein (LDL) levels. It also efficiently raises the serum high-density lipoprotein (HDL) levels. It is known to minimize the incidence of coronary heart diseases in humans.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Gemfibrozil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA0300 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C15H22O3
分子量250.33
EC 号247-280-2
MDL编号MFCD00079335
PubChem化学物质编号329823280
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 363
traceable to PhEur Y0000513
traceable to USP 1288500
储存温度2-8℃
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000513GemfibrozilEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H22O3
分子量250.33
MDL编号MFCD00079335
PubChem化学物质编号329830994
NACRESNA.24

产品性质

等级pharmaceutical primary standard
agencyEP Reference Standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000514Gemfibrozil for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 0.196 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H22O3
分子量250.33
MDL编号MFCD00079335
PubChem化学物质编号329830995
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP363GemfibrozilBritish Pharmacopoeia (BP) Reference Standard1861.35元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H22O3
分子量250.33
EC 号247-280-2
MDL编号MFCD00079335
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1288500USPGemfibrozilUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H22O3
分子量250.33
MDL编号MFCD00079335
PubChem化学物质编号329749930

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
InChI1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI keyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Gene Informationhuman ... PPARA(5465)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
054267Fluorochem5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid95+%264元/1g;   616元/5g;   1276元/25g;   3278元/100g;   咨询

基本信息

CAS Number25812-30-0
MDL NumberMFCD00079335

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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