CAS 256476-36-5; uk-371,804 hcl

CAS:

256476-36-5

分子式:

C₁₄H₁₆ClN₅O₄S·HCl

分子量:

422.29

英文名称:

uk-371,804 hcl

uk-371804 hcl

n-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride

2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride

用途:

UK-371804是一种有效的urokinase-type plasmogen activator (uPA)抑制剂，Ki为10 nM，其选择性良好，对uPA的选择性比对tPA高4000倍，比对plasmin高2700倍。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

U794993

MACKLIN

UK-371804 HCl

10mM in DMSO

834元/1ml;

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储存：-20°C

U872892

MACKLIN

UK-371804 HCl

99%

362元/5mg;

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储存：-20℃
状态：粉末

PZ0344

Sigma-Aldrich

UK-371,804 HCl

≥98% (HPLC)

1088.31元/5 MG; 4394.89元/25 MG;

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产品说明

生化/生理作用

UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₁₄H₁₆ClN₅O₄S · HCl
分子量	422.29
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear (warmed)
创始人	Pfizer
运输	dry ice
储存温度	−20℃
SMILES string	CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable